Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ophtha.2009.02.026
Title: cMET and Refractive Error Progression in Children
Authors: Khor, C.C.
Grignani, R.
Ng, D.P.K. 
Toh, K.Y.
Chia, K.-S. 
Tan, D.
Goh, D.L.M.
Saw, S.-M. 
Issue Date: Aug-2009
Citation: Khor, C.C., Grignani, R., Ng, D.P.K., Toh, K.Y., Chia, K.-S., Tan, D., Goh, D.L.M., Saw, S.-M. (2009-08). cMET and Refractive Error Progression in Children. Ophthalmology 116 (8) : 1469-1474.e1. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ophtha.2009.02.026
Abstract: Objective: To assess whether genetic variation in cMET is associated with refractive error or change in refractive error over time. Design: Cohort study. Participants and Controls: Discovery set (Set 1: N = 579 children; 403 cases, 176 controls). Confirmatory set (Set 2: N = 547 children; 338 cases, 209 controls). Methods: Children in the discovery set were genotyped for a panel of genetic markers within cMET. Markers that were found to be significantly associated with the presence of refractive error or more rapid change in refractive error were then genotyped in the confirmatory set. Main Outcome Measures: Presence or absence of myopia and the rate of change in refractive error over a 3-year follow-up period. Results: Carriage of the variant cMET +110703 A allele was found to associate with increased susceptibility to myopia. The variant was also found to associate with a faster rate of change in refractive error in both the discovery set and the confirmatory cohort regardless of the initial refractory ability (School 1; χ2 for trend P = 0.014) (Schools 2 and 3; χ2 for trend = 5.42, P = 0.020) (combined N = 1126, overall χ2 for trend = 10.90, P = 9.6×10-4). Carriage of the variant allele was also found to be significantly overrepresented in children within the fastest changing quartile (Q4: mean change of -3.01 D over 3 years) compared with the slowest (Q1: mean change of -0.28 D over 3 years) (PSet1 = 0.004, PSet2 = 0.02, Combined N = 559, P = 3.0×10-4). Conclusions: Our data implicate the involvement of cMET in the pathogenesis of myopia in general, as well as more rapid progression in refractive error regardless of the initial refractory ability. These results underline the importance of eye growth genes in the development of common myopia. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2009 American Academy of Ophthalmology.
Source Title: Ophthalmology
URI: http://scholarbank.nus.edu.sg/handle/10635/108301
ISSN: 01616420
DOI: 10.1016/j.ophtha.2009.02.026
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on Jul 17, 2019

WEB OF SCIENCETM
Citations

9
checked on Jul 17, 2019

Page view(s)

40
checked on Jul 19, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.