Please use this identifier to cite or link to this item: https://doi.org/10.1038/nature09270
Title: Biological, clinical and population relevance of 95 loci for blood lipids
Authors: Teslovich, T.M.
Musunuru, K.
Smith, A.V.
Edmondson, A.C.
Stylianou, I.M.
Koseki, M.
Pirruccello, J.P.
Ripatti, S.
Chasman, D.I.
Willer, C.J.
Johansen, C.T.
Fouchier, S.W.
Isaacs, A.
Peloso, G.M.
Barbalic, M.
Ricketts, S.L.
Bis, J.C.
Aulchenko, Y.S.
Thorleifsson, G.
Feitosa, M.F.
Chambers, J.
Orho-Melander, M.
Melander, O.
Johnson, T.
Li, X.
Guo, X.
Li, M.
Shin Cho, Y.
Jin Go, M.
Jin Kim, Y.
Lee, J.-Y.
Park, T.
Kim, K.
Sim, X. 
Twee-Hee Ong, R.
Croteau-Chonka, D.C.
Lange, L.A.
Smith, J.D.
Song, K.
Hua Zhao, J.
Yuan, X.
Luan, J.
Lamina, C.
Ziegler, A.
Zhang, W.
Zee, R.Y.L.
Wright, A.F.
Witteman, J.C.M.
Wilson, J.F.
Willemsen, G.
Wichmann, H.-E.
Whitfield, J.B.
Waterworth, D.M.
Wareham, N.J.
Waeber, G.
Vollenweider, P.
Voight, B.F.
Vitart, V.
Uitterlinden, A.G.
Uda, M.
Tuomilehto, J.
Thompson, J.R.
Tanaka, T.
Surakka, I.
Stringham, H.M.
Spector, T.D.
Soranzo, N.
Smit, J.H.
Sinisalo, J.
Silander, K.
Sijbrands, E.J.G.
Scuteri, A.
Scott, J.
Schlessinger, D.
Sanna, S.
Salomaa, V.
Saharinen, J.
Sabatti, C.
Ruokonen, A.
Rudan, I.
Rose, L.M.
Roberts, R.
Rieder, M.
Psaty, B.M.
Pramstaller, P.P.
Pichler, I.
Perola, M.
Penninx, B.W.J.H.
Pedersen, N.L.
Pattaro, C.
Parker, A.N.
Pare, G.
Oostra, B.A.
O'donnell, C.J.
Nieminen, M.S.
Nickerson, D.A.
Montgomery, G.W.
Meitinger, T.
Mcpherson, R.
Mccarthy, M.I.
Mcardle, W.
Masson, D.
Martin, N.G.
Marroni, F.
Mangino, M.
Magnusson, P.K.E.
Lucas, G.
Luben, R.
Loos, R.J.F.
Lokki, M.-L.
Lettre, G.
Langenberg, C.
Launer, L.J.
Lakatta, E.G.
Laaksonen, R.
Kyvik, K.O.
Kronenberg, F.
König, I.R.
Khaw, K.-T.
Kaprio, J.
Kaplan, L.M.
Johansson, A.
Jarvelin, M.-R.
Cecile J. W. Janssens, A.
Ingelsson, E.
Igl, W.
Kees Hovingh, G.
Hottenga, J.-J.
Hofman, A.
Hicks, A.A.
Hengstenberg, C.
Heid, I.M.
Hayward, C.
Havulinna, A.S.
Hastie, N.D.
Harris, T.B.
Haritunians, T.
Hall, A.S.
Gyllensten, U.
Guiducci, C.
Groop, L.C.
Gonzalez, E.
Gieger, C.
Freimer, N.B.
Ferrucci, L.
Erdmann, J.
Elliott, P.
Ejebe, K.G.
Döring, A.
Dominiczak, A.F.
Demissie, S.
Deloukas, P.
De Geus, E.J.C.
De Faire, U.
Crawford, G.
Collins, F.S.
Chen, Y.-D.I.
Caulfield, M.J.
Campbell, H.
Burtt, N.P.
Bonnycastle, L.L.
Boomsma, D.I.
Boekholdt, S.M.
Bergman, R.N.
Barroso, I.
Bandinelli, S.
Ballantyne, C.M.
Assimes, T.L.
Quertermous, T.
Altshuler, D.
Seielstad, M.
Wong, T.Y. 
Tai, E.-S.
Feranil, A.B.
Kuzawa, C.W.
Adair, L.S.
Taylor Jr., H.A.
Borecki, I.B.
Gabriel, S.B.
Wilson, J.G.
Holm, H.
Thorsteinsdottir, U.
Gudnason, V.
Krauss, R.M.
Mohlke, K.L.
Ordovas, J.M.
Munroe, P.B.
Kooner, J.S.
Tall, A.R.
Hegele, R.A.
Kastelein, J.J.P.
Schadt, E.E.
Rotter, J.I.
Boerwinkle, E.
Strachan, D.P.
Mooser, V.
Stefansson, K.
Reilly, M.P.
Samani, N.J.
Schunkert, H.
Cupples, L.A.
Sandhu, M.S.
Ridker, P.M.
Rader, D.J.
Van Duijn, C.M.
Peltonen, L.
Abecasis, G.R.
Boehnke, M.
Kathiresan, S.
Issue Date: 5-Aug-2010
Citation: Teslovich, T.M., Musunuru, K., Smith, A.V., Edmondson, A.C., Stylianou, I.M., Koseki, M., Pirruccello, J.P., Ripatti, S., Chasman, D.I., Willer, C.J., Johansen, C.T., Fouchier, S.W., Isaacs, A., Peloso, G.M., Barbalic, M., Ricketts, S.L., Bis, J.C., Aulchenko, Y.S., Thorleifsson, G., Feitosa, M.F., Chambers, J., Orho-Melander, M., Melander, O., Johnson, T., Li, X., Guo, X., Li, M., Shin Cho, Y., Jin Go, M., Jin Kim, Y., Lee, J.-Y., Park, T., Kim, K., Sim, X., Twee-Hee Ong, R., Croteau-Chonka, D.C., Lange, L.A., Smith, J.D., Song, K., Hua Zhao, J., Yuan, X., Luan, J., Lamina, C., Ziegler, A., Zhang, W., Zee, R.Y.L., Wright, A.F., Witteman, J.C.M., Wilson, J.F., Willemsen, G., Wichmann, H.-E., Whitfield, J.B., Waterworth, D.M., Wareham, N.J., Waeber, G., Vollenweider, P., Voight, B.F., Vitart, V., Uitterlinden, A.G., Uda, M., Tuomilehto, J., Thompson, J.R., Tanaka, T., Surakka, I., Stringham, H.M., Spector, T.D., Soranzo, N., Smit, J.H., Sinisalo, J., Silander, K., Sijbrands, E.J.G., Scuteri, A., Scott, J., Schlessinger, D., Sanna, S., Salomaa, V., Saharinen, J., Sabatti, C., Ruokonen, A., Rudan, I., Rose, L.M., Roberts, R., Rieder, M., Psaty, B.M., Pramstaller, P.P., Pichler, I., Perola, M., Penninx, B.W.J.H., Pedersen, N.L., Pattaro, C., Parker, A.N., Pare, G., Oostra, B.A., O'donnell, C.J., Nieminen, M.S., Nickerson, D.A., Montgomery, G.W., Meitinger, T., Mcpherson, R., Mccarthy, M.I., Mcardle, W., Masson, D., Martin, N.G., Marroni, F., Mangino, M., Magnusson, P.K.E., Lucas, G., Luben, R., Loos, R.J.F., Lokki, M.-L., Lettre, G., Langenberg, C., Launer, L.J., Lakatta, E.G., Laaksonen, R., Kyvik, K.O., Kronenberg, F., König, I.R., Khaw, K.-T., Kaprio, J., Kaplan, L.M., Johansson, A., Jarvelin, M.-R., Cecile J. W. Janssens, A., Ingelsson, E., Igl, W., Kees Hovingh, G., Hottenga, J.-J., Hofman, A., Hicks, A.A., Hengstenberg, C., Heid, I.M., Hayward, C., Havulinna, A.S., Hastie, N.D., Harris, T.B., Haritunians, T., Hall, A.S., Gyllensten, U., Guiducci, C., Groop, L.C., Gonzalez, E., Gieger, C., Freimer, N.B., Ferrucci, L., Erdmann, J., Elliott, P., Ejebe, K.G., Döring, A., Dominiczak, A.F., Demissie, S., Deloukas, P., De Geus, E.J.C., De Faire, U., Crawford, G., Collins, F.S., Chen, Y.-D.I., Caulfield, M.J., Campbell, H., Burtt, N.P., Bonnycastle, L.L., Boomsma, D.I., Boekholdt, S.M., Bergman, R.N., Barroso, I., Bandinelli, S., Ballantyne, C.M., Assimes, T.L., Quertermous, T., Altshuler, D., Seielstad, M., Wong, T.Y., Tai, E.-S., Feranil, A.B., Kuzawa, C.W., Adair, L.S., Taylor Jr., H.A., Borecki, I.B., Gabriel, S.B., Wilson, J.G., Holm, H., Thorsteinsdottir, U., Gudnason, V., Krauss, R.M., Mohlke, K.L., Ordovas, J.M., Munroe, P.B., Kooner, J.S., Tall, A.R., Hegele, R.A., Kastelein, J.J.P., Schadt, E.E., Rotter, J.I., Boerwinkle, E., Strachan, D.P., Mooser, V., Stefansson, K., Reilly, M.P., Samani, N.J., Schunkert, H., Cupples, L.A., Sandhu, M.S., Ridker, P.M., Rader, D.J., Van Duijn, C.M., Peltonen, L., Abecasis, G.R., Boehnke, M., Kathiresan, S. (2010-08-05). Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466 (7307) : 707-713. ScholarBank@NUS Repository. https://doi.org/10.1038/nature09270
Abstract: Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P
Source Title: Nature
URI: http://scholarbank.nus.edu.sg/handle/10635/108273
ISSN: 00280836
DOI: 10.1038/nature09270
Appears in Collections:Staff Publications

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