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Title: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
Authors: Yamauchi, T.
Hara, K.
Maeda, S.
Yasuda, K.
Takahashi, A.
Horikoshi, M.
Nakamura, M.
Fujita, H.
Grarup, N.
Cauchi, S.
Ng, D.P.K. 
Ma, R.C.W.
Tsunoda, T.
Kubo, M.
Watada, H.
Maegawa, H.
Okada-Iwabu, M.
Iwabu, M.
Shojima, N.
Shin, H.D.
Andersen, G.
Witte, D.R.
Jørgensen, T.
Lauritzen, T.
Sandbæk, A.
Hansen, T.
Ohshige, T.
Omori, S.
Saito, I.
Kaku, K.
Hirose, H.
So, W.-Y.
Beury, D.
Chan, J.C.N.
Park, K.S.
Tai, E.S.
Ito, C.
Tanaka, Y.
Kashiwagi, A.
Kawamori, R.
Kasuga, M.
Froguel, P.
Pedersen, O.
Kamatani, N.
Nakamura, Y.
Kadowaki, T.
Issue Date: Oct-2010
Citation: Yamauchi, T., Hara, K., Maeda, S., Yasuda, K., Takahashi, A., Horikoshi, M., Nakamura, M., Fujita, H., Grarup, N., Cauchi, S., Ng, D.P.K., Ma, R.C.W., Tsunoda, T., Kubo, M., Watada, H., Maegawa, H., Okada-Iwabu, M., Iwabu, M., Shojima, N., Shin, H.D., Andersen, G., Witte, D.R., Jørgensen, T., Lauritzen, T., Sandbæk, A., Hansen, T., Ohshige, T., Omori, S., Saito, I., Kaku, K., Hirose, H., So, W.-Y., Beury, D., Chan, J.C.N., Park, K.S., Tai, E.S., Ito, C., Tanaka, Y., Kashiwagi, A., Kawamori, R., Kasuga, M., Froguel, P., Pedersen, O., Kamatani, N., Nakamura, Y., Kadowaki, T. (2010-10). A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics 42 (10) : 864-868. ScholarBank@NUS Repository.
Abstract: We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10 -9; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10 -9). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10 -14, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D. © 2010 Nature America, Inc.
Source Title: Nature Genetics
ISSN: 10614036
DOI: 10.1038/ng.660
Appears in Collections:Staff Publications

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