Please use this identifier to cite or link to this item: https://doi.org/10.2337/db06-0496
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dc.titleA disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus
dc.contributor.authorNg, D.P.K.
dc.contributor.authorPlacha, G.
dc.contributor.authorChoo, S.
dc.contributor.authorChia, K.-S.
dc.contributor.authorWarram, J.H.
dc.contributor.authorKrolewski, A.S.
dc.date.accessioned2014-11-25T09:43:28Z
dc.date.available2014-11-25T09:43:28Z
dc.date.issued2006-09
dc.identifier.citationNg, D.P.K., Placha, G., Choo, S., Chia, K.-S., Warram, J.H., Krolewski, A.S. (2006-09). A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes 55 (9) : 2660-2663. ScholarBank@NUS Repository. https://doi.org/10.2337/db06-0496
dc.identifier.issn00121797
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108228
dc.description.abstractPrevious investigations of the ACE gene as a susceptibility factor for diabetic nephropathy have primarily focused on its insertion/deletion (Ins/Del) polymorphism. In a departure from these earlier studies, we used three tagging markers (A-5466C, T-3892C, and Ins/Del) at the ACE locus to test for disease haplotype associations. A case-control study design was used where case subjects were type 2 diabetic patients with advanced diabetic nephropathy, as indicated by the presence of proteinuria or chronic renal failure/end-stage renal disease, while control subjects were normoalbuminuric, despite >6 years of diabetes. None of the individual markers showed significant disease association when considered on their own. However, haplotype analyses revealed a near doubling in the prevalence of the A.T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus. © 2006 by the American Diabetes Association.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2337/db06-0496
dc.sourceScopus
dc.subjectACR, albumin-to-creatinine ratio
dc.subjectCRF, chronic renal failure
dc.subjectESRD, end-stage renal disease
dc.subjectIns/Del, insertion/deletion
dc.subjectMAF, minor allele frequency
dc.typeArticle
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.2337/db06-0496
dc.description.sourcetitleDiabetes
dc.description.volume55
dc.description.issue9
dc.description.page2660-2663
dc.description.codenDIAEA
dc.identifier.isiut000240456400033
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