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Title: A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus
Authors: Ng, D.P.K. 
Placha, G.
Choo, S.
Chia, K.-S. 
Warram, J.H.
Krolewski, A.S.
Keywords: ACR, albumin-to-creatinine ratio
CRF, chronic renal failure
ESRD, end-stage renal disease
Ins/Del, insertion/deletion
MAF, minor allele frequency
Issue Date: Sep-2006
Citation: Ng, D.P.K., Placha, G., Choo, S., Chia, K.-S., Warram, J.H., Krolewski, A.S. (2006-09). A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes 55 (9) : 2660-2663. ScholarBank@NUS Repository.
Abstract: Previous investigations of the ACE gene as a susceptibility factor for diabetic nephropathy have primarily focused on its insertion/deletion (Ins/Del) polymorphism. In a departure from these earlier studies, we used three tagging markers (A-5466C, T-3892C, and Ins/Del) at the ACE locus to test for disease haplotype associations. A case-control study design was used where case subjects were type 2 diabetic patients with advanced diabetic nephropathy, as indicated by the presence of proteinuria or chronic renal failure/end-stage renal disease, while control subjects were normoalbuminuric, despite >6 years of diabetes. None of the individual markers showed significant disease association when considered on their own. However, haplotype analyses revealed a near doubling in the prevalence of the A.T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus. © 2006 by the American Diabetes Association.
Source Title: Diabetes
ISSN: 00121797
DOI: 10.2337/db06-0496
Appears in Collections:Staff Publications

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