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|Title:||A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus||Authors:||Ng, D.P.K.
|Keywords:||ACR, albumin-to-creatinine ratio
CRF, chronic renal failure
ESRD, end-stage renal disease
MAF, minor allele frequency
|Issue Date:||Sep-2006||Citation:||Ng, D.P.K., Placha, G., Choo, S., Chia, K.-S., Warram, J.H., Krolewski, A.S. (2006-09). A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes 55 (9) : 2660-2663. ScholarBank@NUS Repository. https://doi.org/10.2337/db06-0496||Abstract:||Previous investigations of the ACE gene as a susceptibility factor for diabetic nephropathy have primarily focused on its insertion/deletion (Ins/Del) polymorphism. In a departure from these earlier studies, we used three tagging markers (A-5466C, T-3892C, and Ins/Del) at the ACE locus to test for disease haplotype associations. A case-control study design was used where case subjects were type 2 diabetic patients with advanced diabetic nephropathy, as indicated by the presence of proteinuria or chronic renal failure/end-stage renal disease, while control subjects were normoalbuminuric, despite >6 years of diabetes. None of the individual markers showed significant disease association when considered on their own. However, haplotype analyses revealed a near doubling in the prevalence of the A.T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus. © 2006 by the American Diabetes Association.||Source Title:||Diabetes||URI:||http://scholarbank.nus.edu.sg/handle/10635/108228||ISSN:||00121797||DOI:||10.2337/db06-0496|
|Appears in Collections:||Staff Publications|
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