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Title: Myopia and age-related cataract: A systematic review and meta-analysis
Authors: Pan, C.-W.
Cheng, C.-Y. 
Saw, S.-M. 
Wang, J.J.
Wong, T.Y. 
Issue Date: Nov-2013
Citation: Pan, C.-W., Cheng, C.-Y., Saw, S.-M., Wang, J.J., Wong, T.Y. (2013-11). Myopia and age-related cataract: A systematic review and meta-analysis. American Journal of Ophthalmology 156 (5) : 1021-1033.e1. ScholarBank@NUS Repository.
Abstract: Purpose To examine if myopia is a risk factor for age-related cataract. Design Systematic review and meta-analysis. Methods A systematic review of the literature was performed using PubMed and Embase from their inception to March 2013 for population-based studies with data on myopia and age-related cataract, including nuclear, cortical, and posterior subcapsular (PSC) cataract. Separate meta-analyses for case-control/cross-sectional studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios (ORs) and relative risks (RRs), respectively. Results A total of 38 007 subjects aged 30-97 years from 12 population-based studies were included in the meta-analysis. Meta-analysis of the 7 cross-sectional studies and 1 case-control study confirmed that myopia was associated with increasingly prevalent nuclear (pooled OR 2.81, 95% CI 1.94-4.06) and PSC cataract (pooled OR 1.93, 95% CI 1.49-2.49) but not with cortical cataract (pooled OR 1.08, 95% CI 0.90-1.30). Meta-analysis from 3 or 4 cohort studies showed nonsignificant associations of myopia with incident nuclear (pooled RR 1.25, 95% CI 0.71-2.21), cortical (pooled RR 1.21, 95% CI 0.67-2.19), and PSC cataract (pooled RR 1.26, 95% CI 0.92-1.74). Conclusions The associations of myopia with prevalent nuclear and PSC cataract are confirmed in meta-analysis of 8 study findings. The association of myopia with incidence of age-related cataract could not be confirmed in meta-analysis of 4 study findings. © 2013 BY ELSEVIER INC. ALL RIGHTS RESERVED.
Source Title: American Journal of Ophthalmology
ISSN: 00029394
DOI: 10.1016/j.ajo.2013.06.005
Appears in Collections:Staff Publications

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