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Title: Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
Authors: Okada, Y.
Sim, X. 
Go, M.J.
Wu, J.-Y.
Gu, D.
Takeuchi, F.
Takahashi, A.
Maeda, S.
Tsunoda, T.
Chen, P.
Lim, S.-C. 
Wong, T.-Y. 
Liu, J.
Young, T.L.
Aung, T.
Seielstad, M.
Teo, Y.-Y. 
Kim, Y.J.
Lee, J.-Y.
Han, B.-G.
Kang, D.
Chen, C.-H.
Tsai, F.-J.
Chang, L.-C.
Cathy Fann, S.-J.C.
Mei, H.
Rao, D.C.
Hixson, J.E.
Chen, S.
Katsuya, T.
Isono, M.
Ogihara, T.
Chambers, J.C.
Zhang, W.
Kooner, J.S.
Albrecht, E.
Yamamoto, K.
Kubo, M.
Nakamura, Y.
Kamatani, N.
Kato, N.
He, J.
Chen, Y.-T.
Cho, Y.S.
Tai, E.-S.
Tanaka, T.
Issue Date: Aug-2012
Citation: Okada, Y., Sim, X., Go, M.J., Wu, J.-Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S.-C., Wong, T.-Y., Liu, J., Young, T.L., Aung, T., Seielstad, M., Teo, Y.-Y., Kim, Y.J., Lee, J.-Y., Han, B.-G., Kang, D., Chen, C.-H., Tsai, F.-J., Chang, L.-C., Cathy Fann, S.-J.C., Mei, H., Rao, D.C., Hixson, J.E., Chen, S., Katsuya, T., Isono, M., Ogihara, T., Chambers, J.C., Zhang, W., Kooner, J.S., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y.-T., Cho, Y.S., Tai, E.-S., Tanaka, T. (2012-08). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics 44 (8) : 904-909. ScholarBank@NUS Repository.
Abstract: Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function. © 2012 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
ISSN: 10614036
DOI: 10.1038/ng.2352
Appears in Collections:Staff Publications

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