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|Title:||Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations||Authors:||Okada, Y.
Cathy Fann, S.-J.C.
|Issue Date:||Aug-2012||Citation:||Okada, Y., Sim, X., Go, M.J., Wu, J.-Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S.-C., Wong, T.-Y., Liu, J., Young, T.L., Aung, T., Seielstad, M., Teo, Y.-Y., Kim, Y.J., Lee, J.-Y., Han, B.-G., Kang, D., Chen, C.-H., Tsai, F.-J., Chang, L.-C., Cathy Fann, S.-J.C., Mei, H., Rao, D.C., Hixson, J.E., Chen, S., Katsuya, T., Isono, M., Ogihara, T., Chambers, J.C., Zhang, W., Kooner, J.S., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y.-T., Cho, Y.S., Tai, E.-S., Tanaka, T. (2012-08). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics 44 (8) : 904-909. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2352||Abstract:||Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function. © 2012 Nature America, Inc. All rights reserved.||Source Title:||Nature Genetics||URI:||http://scholarbank.nus.edu.sg/handle/10635/108209||ISSN:||10614036||DOI:||10.1038/ng.2352|
|Appears in Collections:||Staff Publications|
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