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| Title: | Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma | Authors: | Vithana, E.N. Khor, C.-C. Qiao, C. Nongpiur, M.E. George, R. Chen, L.-J. Do, T. Abu-Amero, K. Huang, C.K. Low, S. Tajudin, L.-S.A. Perera, S.A. Cheng, C.-Y. Xu, L. Jia, H. Ho, C.-L. Sim, K.S. Wu, R.-Y. Tham, C.C.Y. Chew, P.T.K. Su, D.H. Oen, F.T. Sarangapani, S. Soumittra, N. Osman, E.A. Wong, H.-T. Tang, G. Fan, S. Meng, H. Huong, D.T.L. Wang, H. Feng, B. Baskaran, M. Shantha, B. Ramprasad, V.L. Kumaramanickavel, G. Iyengar, S.K. How, A.C. Lee, K.Y. Sivakumaran, T.A. Yong, V.H.K. Ting, S.M.L. Li, Y. Wang, Y.-X. Tay, W.-T. Sim, X. Lavanya, R. Cornes, B.K. Zheng, Y.-F. Wong, T.T. Loon, S.-C. Yong, V.K.Y. Waseem, N. Yaakub, A. Chia, K.-S. Rand Allingham, R. Hauser, M.A. Lam, D.S.C. Hibberd, M.L. Bhattacharya, S.S. Zhang, M. Teo, Y.Y. Tan, D.T. Jonas, J.B. Tai, E.-S. Saw, S.-M. Hon, D.N. Al-Obeidan, S.A. Liu, J. Chau, T.N.B. Simmons, C.P. Bei, J.-X. Zeng, Y.-X. Foster, P.J. Vijaya, L. Wong, T.-Y. Pang, C.-P. Wang, N. Aung, T. |
Issue Date: | Oct-2012 | Citation: | Vithana, E.N., Khor, C.-C., Qiao, C., Nongpiur, M.E., George, R., Chen, L.-J., Do, T., Abu-Amero, K., Huang, C.K., Low, S., Tajudin, L.-S.A., Perera, S.A., Cheng, C.-Y., Xu, L., Jia, H., Ho, C.-L., Sim, K.S., Wu, R.-Y., Tham, C.C.Y., Chew, P.T.K., Su, D.H., Oen, F.T., Sarangapani, S., Soumittra, N., Osman, E.A., Wong, H.-T., Tang, G., Fan, S., Meng, H., Huong, D.T.L., Wang, H., Feng, B., Baskaran, M., Shantha, B., Ramprasad, V.L., Kumaramanickavel, G., Iyengar, S.K., How, A.C., Lee, K.Y., Sivakumaran, T.A., Yong, V.H.K., Ting, S.M.L., Li, Y., Wang, Y.-X., Tay, W.-T., Sim, X., Lavanya, R., Cornes, B.K., Zheng, Y.-F., Wong, T.T., Loon, S.-C., Yong, V.K.Y., Waseem, N., Yaakub, A., Chia, K.-S., Rand Allingham, R., Hauser, M.A., Lam, D.S.C., Hibberd, M.L., Bhattacharya, S.S., Zhang, M., Teo, Y.Y., Tan, D.T., Jonas, J.B., Tai, E.-S., Saw, S.-M., Hon, D.N., Al-Obeidan, S.A., Liu, J., Chau, T.N.B., Simmons, C.P., Bei, J.-X., Zeng, Y.-X., Foster, P.J., Vijaya, L., Wong, T.-Y., Pang, C.-P., Wang, N., Aung, T. (2012-10). Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nature Genetics 44 (10) : 1142-1146. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2390 | Abstract: | Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG. © 2012 Nature America, Inc. All rights reserved. | Source Title: | Nature Genetics | URI: | http://scholarbank.nus.edu.sg/handle/10635/108201 | ISSN: | 10614036 | DOI: | 10.1038/ng.2390 |
| Appears in Collections: | Staff Publications |
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