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Title: Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Authors: Vithana, E.N.
Khor, C.-C. 
Qiao, C.
Nongpiur, M.E.
George, R.
Chen, L.-J.
Do, T.
Abu-Amero, K.
Huang, C.K.
Low, S.
Tajudin, L.-S.A.
Perera, S.A.
Cheng, C.-Y. 
Xu, L.
Jia, H.
Ho, C.-L.
Sim, K.S.
Wu, R.-Y.
Tham, C.C.Y.
Chew, P.T.K.
Su, D.H.
Oen, F.T.
Sarangapani, S.
Soumittra, N.
Osman, E.A.
Wong, H.-T.
Tang, G.
Fan, S.
Meng, H.
Huong, D.T.L.
Wang, H.
Feng, B.
Baskaran, M.
Shantha, B.
Ramprasad, V.L.
Kumaramanickavel, G.
Iyengar, S.K.
How, A.C.
Lee, K.Y.
Sivakumaran, T.A.
Yong, V.H.K.
Ting, S.M.L.
Li, Y.
Wang, Y.-X.
Tay, W.-T.
Sim, X. 
Lavanya, R.
Cornes, B.K.
Zheng, Y.-F.
Wong, T.T.
Loon, S.-C.
Yong, V.K.Y.
Waseem, N.
Yaakub, A.
Chia, K.-S. 
Rand Allingham, R.
Hauser, M.A.
Lam, D.S.C.
Hibberd, M.L. 
Bhattacharya, S.S.
Zhang, M.
Teo, Y.Y. 
Tan, D.T.
Jonas, J.B.
Tai, E.-S.
Saw, S.-M. 
Hon, D.N.
Al-Obeidan, S.A.
Liu, J. 
Chau, T.N.B.
Simmons, C.P.
Bei, J.-X.
Zeng, Y.-X.
Foster, P.J.
Vijaya, L.
Wong, T.-Y. 
Pang, C.-P.
Wang, N.
Aung, T.
Issue Date: Oct-2012
Citation: Vithana, E.N., Khor, C.-C., Qiao, C., Nongpiur, M.E., George, R., Chen, L.-J., Do, T., Abu-Amero, K., Huang, C.K., Low, S., Tajudin, L.-S.A., Perera, S.A., Cheng, C.-Y., Xu, L., Jia, H., Ho, C.-L., Sim, K.S., Wu, R.-Y., Tham, C.C.Y., Chew, P.T.K., Su, D.H., Oen, F.T., Sarangapani, S., Soumittra, N., Osman, E.A., Wong, H.-T., Tang, G., Fan, S., Meng, H., Huong, D.T.L., Wang, H., Feng, B., Baskaran, M., Shantha, B., Ramprasad, V.L., Kumaramanickavel, G., Iyengar, S.K., How, A.C., Lee, K.Y., Sivakumaran, T.A., Yong, V.H.K., Ting, S.M.L., Li, Y., Wang, Y.-X., Tay, W.-T., Sim, X., Lavanya, R., Cornes, B.K., Zheng, Y.-F., Wong, T.T., Loon, S.-C., Yong, V.K.Y., Waseem, N., Yaakub, A., Chia, K.-S., Rand Allingham, R., Hauser, M.A., Lam, D.S.C., Hibberd, M.L., Bhattacharya, S.S., Zhang, M., Teo, Y.Y., Tan, D.T., Jonas, J.B., Tai, E.-S., Saw, S.-M., Hon, D.N., Al-Obeidan, S.A., Liu, J., Chau, T.N.B., Simmons, C.P., Bei, J.-X., Zeng, Y.-X., Foster, P.J., Vijaya, L., Wong, T.-Y., Pang, C.-P., Wang, N., Aung, T. (2012-10). Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nature Genetics 44 (10) : 1142-1146. ScholarBank@NUS Repository.
Abstract: Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG. © 2012 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
ISSN: 10614036
DOI: 10.1038/ng.2390
Appears in Collections:Staff Publications

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