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Title: Assessment of iris surface features and their relationship with iris thickness in Asian eyes
Authors: Sidhartha, E.
Gupta, P.
Liao, J.
Tham, Y.-C.
Cheung, C.Y.
He, M.
Wong, T.Y. 
Aung, T.
Cheng, C.-Y. 
Issue Date: 2014
Citation: Sidhartha, E., Gupta, P., Liao, J., Tham, Y.-C., Cheung, C.Y., He, M., Wong, T.Y., Aung, T., Cheng, C.-Y. (2014). Assessment of iris surface features and their relationship with iris thickness in Asian eyes. Ophthalmology 121 (5) : 1007-1012. ScholarBank@NUS Repository.
Abstract: Purpose To assess iris surface features in Asian eyes and examine their associations with iris thickness measured by anterior segment optical coherence tomography (AS OCT). Design Cross-sectional study. Participants We recruited 250 subjects from the Singapore Malay Eye Study. Methods We obtained standardized slit-lamp photographs and developed a grading system assessing iris crypts (by number and size), furrows (by number and circumferential extent), and color (higher grade denoting darker iris). Vertical and horizontal cross-sections of the anterior chamber were imaged using AS OCT. Intragrader and intergrader agreements in the grading of iris surface were assessed by weighted κ (κw) statistic. Associations of the average iris thickness with the grade of iris features were assessed using linear regression analysis. Main Outcome Measures Frequency and size of iris crypts, furrows, and color; iris thickness at 750 μm (IT750) and 2000 μm (IT2000) from the scleral spur; and maximum iris thickness (ITM) averaged from the 4 quarters. Results Three hundred sixty-four eyes had complete and gradable data for crypts and color; 330 eyes were graded for furrows. The grading scheme showed good intragrader (crypt κw = 0.919, furrow κw =0.901, color κw = 0.925) and intergrader (crypt κw = 0.775, furrow κw = 0.836, color κw = 0.718) agreements. Higher crypt grade was associated independently with thinner IT750 (β [change in iris thickness per grade higher] = -0.007; P = 0.029), IT2000 (β = -0.018; P
Source Title: Ophthalmology
ISSN: 15494713
DOI: 10.1016/j.ophtha.2013.11.028
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