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Title: Pharmacogenetics: Role in modifying drug dosage regimens
Authors: Mah, J.T.L. 
Wong, J.Y.Y.
Lee, E.J.D. 
Keywords: Adverse drug reactions
Drug development
Genetic polymorphism
Issue Date: Sep-2000
Citation: Mah, J.T.L.,Wong, J.Y.Y.,Lee, E.J.D. (2000-09). Pharmacogenetics: Role in modifying drug dosage regimens. Annals of the Academy of Medicine Singapore 29 (5) : 628-632. ScholarBank@NUS Repository.
Abstract: With the advent of new molecular biology and scientific techniques, there is better understanding of genetic polymorphisms in oxidative drug metabolism systems today. These systems are important in pharmacogenetic studies which genotype polymorphic alleles encoding drug metabolising enzymes to enable the individual's drug metabolising phenotype to be found. Once found, the knowledge can be used to tailor drug dosage regimens to an individual to maximise therapeutic efficacy and minimise adverse drug reactions (ADRs). The knowledge could also be used to optimise drug development programmes so that all the subgroups within a target population are adequately represented in clinical trails.
Source Title: Annals of the Academy of Medicine Singapore
ISSN: 03044602
Appears in Collections:Staff Publications

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