Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuroscience.2003.10.050
Title: Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: A magnetic resonance imaging study
Authors: Shirhan, M.D. 
Moochhala, S.M. 
Ng, P.-Y.
Lu, J.
Ng, K.C.
Teo, A.L.
Yap, E.
Ng, I.
Hwang, P.
Lim, T.
Sitoh, Y.Y.
Rumpel, H.
Jose, R.
Ling, E. 
Keywords: MRI
Nitric oxide
Polyamine
TTC staining
Issue Date: 2004
Citation: Shirhan, M.D., Moochhala, S.M., Ng, P.-Y., Lu, J., Ng, K.C., Teo, A.L., Yap, E., Ng, I., Hwang, P., Lim, T., Sitoh, Y.Y., Rumpel, H., Jose, R., Ling, E. (2004). Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: A magnetic resonance imaging study. Neuroscience 124 (2) : 299-304. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroscience.2003.10.050
Abstract: The role of nitric oxide (NO) in post-ischemic cerebral infarction has been extensively examined, but few studies have investigated its role on the neurological deficit. In the present study, we investigated the effect of spermine on the temporal evolution of infarct volume, NO production and neurological deficit using magnetic resonance imaging in a model of permanent focal cerebral ischemia in rats. Spermine given at 10 mg/kg 2 h after ischemia reduced the infarct volume by 40% and abolished brain NO production and improved the neurological score 24 h, 48 h and 72 h after ischemia. Spermine also reduced the neurological deficit as evaluated by rotamex, grip strength and neurological severity score tests. © 2004 IBRO. Published by Elsevier Ltd. All rights reserved.
Source Title: Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/108092
ISSN: 03064522
DOI: 10.1016/j.neuroscience.2003.10.050
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