Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/108089
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dc.titleTargeting of liposomes via passively-adsorbed monclonal antibodies to human hepatocellular carcinoma cells in vitro
dc.contributor.authorTan, L.
dc.contributor.authorGregoriadis, G.
dc.date.accessioned2014-11-20T05:58:45Z
dc.date.available2014-11-20T05:58:45Z
dc.date.issued1990
dc.identifier.citationTan, L.,Gregoriadis, G. (1990). Targeting of liposomes via passively-adsorbed monclonal antibodies to human hepatocellular carcinoma cells in vitro. Asia Pacific Journal of Pharmacology 5 (3) : 219-222. ScholarBank@NUS Repository.
dc.identifier.issn02179687
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108089
dc.description.abstractSmall unilamellar vesicles (SUV) were coated with monoclonal antibodies RF-HCC1 (IgG1), RF-HCC2 (IgM) and MOPC 21 IgG1, which bind to surface antigens on Mahlavu cells, by passive adsorption. Adsorption values for the three antibodies were 35.1%, 51.6% and 12.2% respectively. On incubation of the liposomes containing the aqueous marker carbocyfluorescein (CF) with Mahlavu cells in vitro at 4°C, it was seen that binding of antibody and association of CF with cells took place in a biphasic manner with maximal binding occuring by 1 hour followed by a plateau phase. These results indicate that passively-adsorbed antibodies represent a rapid, conventient and effective method of ligand-mediated targeting of SUV to cells in vitro.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.sourcetitleAsia Pacific Journal of Pharmacology
dc.description.volume5
dc.description.issue3
dc.description.page219-222
dc.description.codenAPJPE
dc.identifier.isiutNOT_IN_WOS
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