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Title: Population genetics of the angiotensin-converting enzyme in Chinese
Authors: Lee, E.J.D. 
Issue Date: 1994
Citation: Lee, E.J.D. (1994). Population genetics of the angiotensin-converting enzyme in Chinese. British Journal of Clinical Pharmacology 37 (2) : 212-214. ScholarBank@NUS Repository.
Abstract: A genetic polymorphism exists for the angiotensin-converting enzyme (ACE) gene which accounts for 44% of the variance of circulating ACE activity in a normal Caucasian population. The presence or absence of a 250 bp fragment in intron 16 of the gene serves as a marker for this polymorphism. One hundred and eighty-nine normal Chinese subjects were genotyped and phenotyped for this ACE polymorphism. The frequencies of the deletion and insertion alleles among Chinese are 0.3 and 0.7 respectively, indicating a much higher prevalence of the insertion allele than had been reported among Caucasians.
Source Title: British Journal of Clinical Pharmacology
ISSN: 03065251
Appears in Collections:Staff Publications

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