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Title: Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia
Authors: Chong, S.-A.
Lee, W.-L.
Tan, C.-H. 
Hou-NgeeTay, A.
Oi-Mei Chan, A.
Tan, E.-C.
Keywords: 5-HTTLPR
Polymerase chain reaction
Issue Date: 27-Dec-2000
Citation: Chong, S.-A., Lee, W.-L., Tan, C.-H., Hou-NgeeTay, A., Oi-Mei Chan, A., Tan, E.-C. (2000-12-27). Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia. Psychiatry Research 97 (2-3) : 101-106. ScholarBank@NUS Repository.
Abstract: Abnormalities of serotonin synthesis and metabolism may be associated with suicidality. The serotonin transporter gene (5-HTT) is one of the important genes involved in the regulation of serotonin neurotransmission. We examined the association of suicidal behavior in Chinese schizophrenic patients with a functional polymorphism of the promoter region of the 5-HTT gene (5-HTTLPR). The 5-HTTLPR genotype was determined by polymerase chain reaction for 76 suicidal and 262 non-suicidal patients with a diagnosis of schizophrenia (DSM-IV criteria). All subjects were unrelated to each other, and all were Chinese. There was no significant genotypic or allelic association of the 5-HTTLPR polymorphism with history of attempted suicide. From our results, this 5-HTTLPR polymorphism is unlikely to have a major effect on suicidal behavior in Chinese patients with schizophrenia. © 2000 Elsevier Science Ltd.
Source Title: Psychiatry Research
ISSN: 01651781
DOI: 10.1016/S0165-1781(00)00229-8
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