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Title: Influence of selective nitric oxide synthetase inhibitor for treatment of refractory haemorrhagic shock
Authors: Shirhan, Md. 
Moochhala, S.M. 
Kerwin, S.-Y.L. 
Ng, K.C.
Lu, J.
Keywords: Aminoguanidina
Choque hemorrágico
Haemorrhagic shock
Nitric oxide
Oxido nítrico
SOC hemorrágico
Issue Date: May-2004
Citation: Shirhan, Md., Moochhala, S.M., Kerwin, S.-Y.L., Ng, K.C., Lu, J. (2004-05). Influence of selective nitric oxide synthetase inhibitor for treatment of refractory haemorrhagic shock. Resuscitation 61 (2) : 221-229. ScholarBank@NUS Repository.
Abstract: Objective: Haemorrhagic shock (HS) is implicated in the induction of inducible nitric oxide synthase that leads to increased production of nitric oxide (NO). We investigated the influence of aminoguanidine (AG), a selective iNOS inhibitor, N G-nitro-L-arginine methyl ester (L-NAME), a non-selective inhibitor and S-Nitroso-N-acetylpenicillamine (SNAP), a NO donor, each of which was given with (+) or without (-) angiotensin II (ANGII), a vasoconstrictor, on the survival rate of HS decompensatory phased (HSDP) rats. Materials and methods: HSDP was achieved via a constant pressure method. Organs were harvested and analyzed from rats sacrificed 72 h after HSDP or upon death. Plasma collected from HSDP rats were used to measure nitrate/nitrite, GOT and creatinine levels. Results: AG+ANGII-treated rats had significantly higher survival rates compared to the other treatment groups, 72 h following HSDP. A marked increase in MABP level was observed in AG+ANGII-treated rats when compared to other treatment groups. Histological examinations also showed a reduction of organ damage in AG+ANGII-treated rats compared to other treatment groups. Nitrate/nitrite level, glutamic oxalacetic transaminase (GOT) level and creatinine level were also significantly improved in AG+ANGII-treated rats compared to the other groups. Conclusions: A greater beneficial effect was achieved with treatment by the AG+ANGII combination. Our experiments showed that the inhibition of excessive NO formation that occurred during HSDP, had augmented the vascular responsiveness effect of ANGII following protracted HS. © 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Resuscitation
ISSN: 03009572
DOI: 10.1016/j.resuscitation.2004.01.005
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