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|Title:||Differences in anxiety-related behavior between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice||Authors:||McLachlan, C.S.
Yi Xing Soh, C.
Elevated plus maze
|Issue Date:||2005||Citation:||McLachlan, C.S.,Yi Xing Soh, C. (2005). Differences in anxiety-related behavior between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice. Physiological Research 54 (6) : 701-704. ScholarBank@NUS Repository.||Abstract:||The influence of ApoE gene deletion on the anxiety state has not been previously investigated. The elevated plus maze was used in this study to determine differences in anxiety-related behavior between apoE-deficient and wild type C57BL/6 mice. The apoE-deficient mice demonstrated less anxiety on the elevated plus maze by spending more time in the open arms of the elevated plus maze compared to wild type mice (p<0.001). Additionally, female apoE-deficient mice visited the open arm of the maze more often than their apoE-deficient male counterpart (p<0.05). The anxiety state and/or sex are possible variables to be considered when designing physiological and/or behavioral studies involving mice that are apoE-deficient. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.||Source Title:||Physiological Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/108056||ISSN:||08628408|
|Appears in Collections:||Staff Publications|
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