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Please use this identifier to cite or link to this item: https://doi.org/10.1002/pmic.200401084
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dc.titleProteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma
dc.contributor.authorLuk, J.M.
dc.contributor.authorSu, Y.C.F.
dc.contributor.authorLam, S.C.T.
dc.contributor.authorLee, C.K.
dc.contributor.authorHu, M.Y.
dc.contributor.authorHe, Q.Y.
dc.contributor.authorLau, G.K.
dc.contributor.authorWong, F.W.S.
dc.contributor.authorFan, S.-T.
dc.date.accessioned2014-11-20T05:58:22Z
dc.date.available2014-11-20T05:58:22Z
dc.date.issued2005-05
dc.identifier.citationLuk, J.M., Su, Y.C.F., Lam, S.C.T., Lee, C.K., Hu, M.Y., He, Q.Y., Lau, G.K., Wong, F.W.S., Fan, S.-T. (2005-05). Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma. Proteomics 5 (7) : 1980-1986. ScholarBank@NUS Repository. https://doi.org/10.1002/pmic.200401084
dc.identifier.issn16159853
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108053
dc.description.abstractA murine monoclonal antibody (mAb), CLD3 (IgG1,κ), was generated against hepatocellular carcinoma (HCC). Both immunofluorescence and immunohistochemical assays indicated the reactivity of CLD3 mAb localized at the nucleus and/or cytoplasm of tumorigenic HCC cell lines as well as in liver cancer tissues. By immunoprecipitation and using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry approach, the antigenic specificity of CLD3 was determined to be heterodimeric Ku70 and Ku80 autoantigen, which was confirmed by Western blotting. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/pmic.200401084
dc.sourceScopus
dc.subjectHepatocellular carcinoma
dc.subjectKu autoantigen
dc.subjectMonoclonal antibody
dc.subjectTumor marker
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1002/pmic.200401084
dc.description.sourcetitleProteomics
dc.description.volume5
dc.description.issue7
dc.description.page1980-1986
dc.description.codenPROTC
dc.identifier.isiut000229321000023
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