Please use this identifier to cite or link to this item:
Title: Histogenesis of true splenic cysts: a histological and immunohistochemical study.
Authors: Lee, Y.S. 
Teh, M. 
Issue Date: May-1993
Citation: Lee, Y.S.,Teh, M. (1993-05). Histogenesis of true splenic cysts: a histological and immunohistochemical study.. Annals of the Academy of Medicine Singapore 22 (3) : 372-376. ScholarBank@NUS Repository.
Abstract: Three true splenic cysts were studied histologically and immunohistochemically using antibodies against Ber-EP4, CEA, factor-VIII related antigen and several cytokeratins of varying molecular weights. Two cysts were lined by cuboidal and columnar cells with extensive squamous metaplasia. The columnar cells have the immunophenotype of mesothelial cells being positive for keratin but negative for Ber-EP4 and CEA. The third cyst occurred in a wandering spleen and was lined by hobnail columnar cells with cilia resembling tubal epithelium of Fallopian tube. The immunophenotype was that of epithelial cells being positive for both keratin and Ber-EP4. It is likely that true splenic cysts originate from invagination of the capsular mesothelial lining. The frequent occurrence of stratified squamous epithelium is attributed to squamous metaplasia secondary to haemorrhage and irritation. On the other hand, the presence of tubal epithelium in true splenic cysts is more likely to be due to the innate potentiality of mesothelial cells to differentiate along Mullerian line and may be a manifestation of the secondary Mullerian system. The cyst lining cells were negative for factor-VIII related antigen and thus offered no support for an origin from endothelium.
Source Title: Annals of the Academy of Medicine Singapore
ISSN: 03044602
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Jun 21, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.