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Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/107995
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dc.titleEffects of genistein on ATP induced DNA synthesis and intracellular alkalinization in Chang liver cells
dc.contributor.authorSit, K.-H.
dc.contributor.authorWong, K.-P.
dc.contributor.authorBay, B.-H.
dc.date.accessioned2014-11-20T05:57:49Z
dc.date.available2014-11-20T05:57:49Z
dc.date.issued1991
dc.identifier.citationSit, K.-H., Wong, K.-P., Bay, B.-H. (1991). Effects of genistein on ATP induced DNA synthesis and intracellular alkalinization in Chang liver cells. Japanese Journal of Pharmacology 57 (1) : 109-111. ScholarBank@NUS Repository.
dc.identifier.issn00215198
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107995
dc.description.abstractExtracellular ATP (adenosine 5'-triphosphate) produces a dose-dependent elevation of DNA synthesis concomitantly with raised intracellular pH (pH(i)) in quiescent monolayer Chang liver cells; Genistein produces a dose-dependent suppression of ATP-induced DNA synthesis without affecting cell viability (dead cell index ≃ 5%) or pH(i) elevation. The results suggest that (a) mitogenesis and pH(i) are not imperative correlates and (b) genistein is effective in inhibiting DNA synthesis whether due to growth factor or ″non-growth factor″ stimulation.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentANATOMY
dc.contributor.departmentBIOCHEMISTRY
dc.description.sourcetitleJapanese Journal of Pharmacology
dc.description.volume57
dc.description.issue1
dc.description.page109-111
dc.description.codenJJPAA
dc.identifier.isiutNOT_IN_WOS
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