Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.pscychresns.2007.07.005
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dc.titleVolumetrics of the caudate nucleus: Reliability and validity of a new manual tracing protocol
dc.contributor.authorLooi, J.C.L.
dc.contributor.authorLindberg, O.
dc.contributor.authorLiberg, B.
dc.contributor.authorTatham, V.
dc.contributor.authorKumar, R.
dc.contributor.authorMaller, J.
dc.contributor.authorMillard, E.
dc.contributor.authorSachdev, P.
dc.contributor.authorHögberg, G.
dc.contributor.authorPagani, M.
dc.contributor.authorBotes, L.
dc.contributor.authorEngman, E.-L.
dc.contributor.authorZhang, Y.
dc.contributor.authorSvensson, L.
dc.contributor.authorWahlund, L.-O.
dc.date.accessioned2014-11-20T03:16:36Z
dc.date.available2014-11-20T03:16:36Z
dc.date.issued2008-08-30
dc.identifier.citationLooi, J.C.L., Lindberg, O., Liberg, B., Tatham, V., Kumar, R., Maller, J., Millard, E., Sachdev, P., Högberg, G., Pagani, M., Botes, L., Engman, E.-L., Zhang, Y., Svensson, L., Wahlund, L.-O. (2008-08-30). Volumetrics of the caudate nucleus: Reliability and validity of a new manual tracing protocol. Psychiatry Research - Neuroimaging 163 (3) : 279-288. ScholarBank@NUS Repository. https://doi.org/10.1016/j.pscychresns.2007.07.005
dc.identifier.issn09254927
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107943
dc.description.abstractOur aim was to develop a reliable and valid manual segmentation protocol for tracing the caudate nucleus in MRI for volumetric and, potentially, shape analysis of the caudate. Using the protocol, two inter- and intra-rater reliability studies were conducted using five different raters on two different image analysis platforms (ANALYZE, Mayo Biomedical Imaging Resource, Rochester MN, USA, and HERMES, Nuclear Diagnostics AB, Stockholm, Sweden). Reference images for the detailed protocol are described. Two studies were performed. In study 1, the intra-rater class correlation ICC(1,1) for an experienced rater (JCLL) using this protocol for caudate nucleus volumes was evaluated by repeating right and left caudate measurements on 10 scans (20 comparisons) and was 0.972. The inter-rater class correlation ICC(1,k) with OL was 0.922 on 5 scans (10 comparisons) and with BL was 0.960 on 5 scans (10 comparisons). In study 2, VT obtained an intra-rater class correlation of 0.9 on 5 scans (involving 10 comparisons, e.g. right and left caudate). The inter-rater class correlation ICC(1,k) was 0.988 on 5 scans (again involving 10 comparisons) with EM. We therefore developed a novel, reliable and reference image-based, method of outlining the caudate nucleus on axial MRI scans, usable in two different image analysis laboratories, across two different sets number of tracers reliably, and across software platforms. This method is therefore potentially usable for any image analysis package capable of displaying and measuring outlined voxels from MRI brain scans. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.pscychresns.2007.07.005
dc.sourceScopus
dc.subjectCaudate
dc.subjectMRI
dc.subjectReliability
dc.subjectROI
dc.subjectTracing
dc.subjectVOI
dc.subjectVolumentrics
dc.typeArticle
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1016/j.pscychresns.2007.07.005
dc.description.sourcetitlePsychiatry Research - Neuroimaging
dc.description.volume163
dc.description.issue3
dc.description.page279-288
dc.description.codenPSREE
dc.identifier.isiut000259133000009
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