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Title: The relationship between nasopharyngeal carcinoma tumor volume and TNM T-classification: A quantitative analysis
Authors: Zhou, J.-Y.
Chong, V.F.H. 
Khoo, J.B.K.
Chan, K.-L.
Huang, J.
Keywords: Nasopharyngeal carcinoma
Prognostic factor
TNM classification
Tumor volume
Issue Date: Feb-2007
Citation: Zhou, J.-Y., Chong, V.F.H., Khoo, J.B.K., Chan, K.-L., Huang, J. (2007-02). The relationship between nasopharyngeal carcinoma tumor volume and TNM T-classification: A quantitative analysis. European Archives of Oto-Rhino-Laryngology 264 (2) : 169-174. ScholarBank@NUS Repository.
Abstract: Recent findings show that tumor volume is a significant prognostic factor for the treatment of nasopharyngeal carcinoma (NPC). The inclusion of tumor volume as an additional prognostic factor in the UICC TNM classification system was suggested; however, how tumor volume could possibly be incorporated is still unexplored. In this paper, we report a quantitative analysis on the relationship between NPC tumor volume and T-classification, using the data from 206 NPC patients. By T-classification and semi-automatic tumor volume measurement, the difference in tumor volumes among the various TNM T-classification groups was examined. In addition, a statistics-based analysis scheme, which used the T-classification as the "gold standard", was proposed to classify NPC tumors into volume-based groups to explore the possible links. The results show that NPC tumor volume has positive correlation with advancing T-classification groups and significant difference existed in the distribution of T-classification among various volume-based groups (P < 0.001). By the proposed statistical scheme, tumor volume could be included as an additional prognostic factor in the TNM framework, following validation studies. © 2006 Springer-Verlag.
Source Title: European Archives of Oto-Rhino-Laryngology
ISSN: 09374477
DOI: 10.1007/s00405-006-0163-2
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