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Title: GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin
Authors: Zhang, K.
Yang, E.B.
Wong, K.P. 
Mack, P.
Keywords: Adriamycin
Glutathione conjugate export pump
Glutathione peroxidase
Glutathione reductase
Glutathione S-transferase
Issue Date: May-1999
Citation: Zhang, K.,Yang, E.B.,Wong, K.P.,Mack, P. (1999-05). GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin. International Journal of Oncology 14 (5) : 861-867. ScholarBank@NUS Repository.
Abstract: Glutathione (GSH) contents and activities of glutathione S-transferase (GST), glutathione reductase (GSH-RD), glutathione peroxidase (GSHpx) and glutathione conjugate export pump (GS-X pump) were determined in eight human tumor cell lines with different sensitivities to adriamycin and chlorambucil. Correlations between sensitivities of the human tumor cells to adriamycin and chlorambucil and the glutathione related factors were analyzed statistically. Sensitivities of the human tumor cells to chlorambucil were found to be correlated to all the glutathione related factors tested (r=0.68-0.88). IC 50 values of adriamycin were also positively correlated to GSH contents and activities of GSH-RD, GSHpx and GS-X pump with r values ranging from 0.66 to 0.77 but not to GST activity (r=0.25). Chang liver cells with highest GSH content and highest activities of GST, GSH-RD, GSHpx and GS-X pump were most resistant to both adriamycin and chlorambucil. These data suggested that glutathione related factors may work as an overall detoxification system participating in the detoxification of anticancer drugs such as adriamycin and chlorambucil, and to be involved in cellular resistance to these drugs.
Source Title: International Journal of Oncology
ISSN: 10196439
Appears in Collections:Staff Publications

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