Please use this identifier to cite or link to this item: https://doi.org/10.1089/ars.2007.1929
DC FieldValue
dc.titleMitochondria-directed therapeutics
dc.contributor.authorArmstrong, J.S.
dc.date.accessioned2014-11-10T09:42:51Z
dc.date.available2014-11-10T09:42:51Z
dc.date.issued2008-03-01
dc.identifier.citationArmstrong, J.S. (2008-03-01). Mitochondria-directed therapeutics. Antioxidants and Redox Signaling 10 (3) : 575-578. ScholarBank@NUS Repository. https://doi.org/10.1089/ars.2007.1929
dc.identifier.issn15230864
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107751
dc.description.abstractMitochondria are key regulators of cell life and death and play an important role in a wide range of diseases, including cancer, diabetes, cardiovascular disease, and the age-related neurodegenerative diseases. The unique structural and functional characteristics of mitochondria enable the selective targeting of drugs designed to modulate the function of this organelle for therapeutic gain. This forum discusses (a) potential new mitochondrial targets for therapeutic intervention, including components of the electron transport chain, the permeability transition, and the membrane dynamics protein mitofusin-2; (b) the role of mitochondria-targeted antioxidants including MitoQ and SS peptides in modulating reactive oxygen and chlorine species induced mitochondrial permeabilization and cell death; and (c) the potential use of SS peptides in ischemia and reperfusion tissue injury. In the future, mitochondrial drug-targeting strategies will be expected to open up avenues for manipulating mitochondrial functions and allow for selective protection or eradication of cells for therapeutic gain in a variety of diseases. © 2008 Mary Ann Liebert, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1089/ars.2007.1929
dc.sourceScopus
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1089/ars.2007.1929
dc.description.sourcetitleAntioxidants and Redox Signaling
dc.description.volume10
dc.description.issue3
dc.description.page575-578
dc.description.codenARSIF
dc.identifier.isiut000252559700008
Appears in Collections:Staff Publications

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