Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/107722
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dc.titleGenes, diet and serum lipid concentrations: Lessons from ethnically diverse populations and their relevance to coronary heart disease in Asia
dc.contributor.authorTai, E.S.
dc.contributor.authorChee, E.T.
dc.date.accessioned2014-11-10T09:20:31Z
dc.date.available2014-11-10T09:20:31Z
dc.date.issued2004-02
dc.identifier.citationTai, E.S., Chee, E.T. (2004-02). Genes, diet and serum lipid concentrations: Lessons from ethnically diverse populations and their relevance to coronary heart disease in Asia. Current Opinion in Lipidology 15 (1) : 5-12. ScholarBank@NUS Repository.
dc.identifier.issn09579672
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107722
dc.description.abstractPurpose of review: The burden of coronary heart disease (CHD) in Asia has risen in tandem with socio-economic development and urbanization. Although all ethnic groups have been affected, some appear to be at particularly high risk. The basis of these ethnic differences remains poorly understood. Recent findings: Differing levels of risk factors for CHD have been observed between ethnic groups. Previous studies, however, may be confounded by a large ethnic variation in socio-economic status and place of residence. Few studies have taken dietary factors into account. Recent studies involving Chinese, Malays and Asian Indians living in Singapore suggest that neither dietary nor genetic factors, taken in isolation, sufficiently explain ethnic differences in serum lipid profiles. Several genetic variants in key candidate genes (apolipoprotein E, APOE, cholesteryl ester transfer protein, CETP and hepatic lipase, LIPC) have recently been found to modulate the association between dietary factors and serum lipid concentrations in these ethnic groups and in other populations. Summary: To fully evaluate the differences in CHD risk between ethnic groups, environmental exposures, including dietary factors need to be carefully evaluated, and gene-environment interactions that may give rise to these differences need to be taken into account. These are critical steps in the development of targeted strategies to contain the epidemic of coronary heart disease in Asia. An understanding of the basis of these differences may also provide insights into the pathogenesis of disease that one cannot get through the examination of more homogenous populations. © 2004 Lippincott Williams & Wilkins.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1097/00041433-200402000-00003
dc.sourceScopus
dc.subjectCoronary heart disease
dc.subjectDiet
dc.subjectEthnic groups
dc.subjectGenetics
dc.subjectLipids
dc.typeReview
dc.contributor.departmentMEDICINE
dc.contributor.departmentCENTRE FOR MOLECULAR EPIDEMIOLOGY
dc.description.sourcetitleCurrent Opinion in Lipidology
dc.description.volume15
dc.description.issue1
dc.description.page5-12
dc.description.codenCOPLE
dc.identifier.isiut000220228700002
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