Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.ejogrb.2003.09.011
DC Field | Value | |
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dc.title | Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery | |
dc.contributor.author | Chong, Y.-S. | |
dc.contributor.author | Chua, S. | |
dc.contributor.author | Shen, L. | |
dc.contributor.author | Arulkumaran, S. | |
dc.date.accessioned | 2014-11-10T08:04:02Z | |
dc.date.available | 2014-11-10T08:04:02Z | |
dc.date.issued | 2004-04-15 | |
dc.identifier.citation | Chong, Y.-S., Chua, S., Shen, L., Arulkumaran, S. (2004-04-15). Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery. European Journal of Obstetrics Gynecology and Reproductive Biology 113 (2) : 191-198. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejogrb.2003.09.011 | |
dc.identifier.issn | 03012115 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/107607 | |
dc.description.abstract | Objective: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes. Study design: Fifty women were given misoprostol 400μg either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters. Results: Uterine activity produced by oral solution misoprostol 400μg was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively). Conclusion: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects. © 2003 Elsevier Ireland Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ejogrb.2003.09.011 | |
dc.source | Scopus | |
dc.subject | Misoprostol | |
dc.subject | Postpartum haemorrhage | |
dc.subject | Route of administration | |
dc.subject | Side effects | |
dc.subject | Uterotonic | |
dc.type | Article | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.description.doi | 10.1016/j.ejogrb.2003.09.011 | |
dc.description.sourcetitle | European Journal of Obstetrics Gynecology and Reproductive Biology | |
dc.description.volume | 113 | |
dc.description.issue | 2 | |
dc.description.page | 191-198 | |
dc.description.coden | EOGRA | |
dc.identifier.isiut | 000220945100014 | |
Appears in Collections: | Staff Publications |
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