Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejogrb.2003.09.011
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dc.titleDoes the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery
dc.contributor.authorChong, Y.-S.
dc.contributor.authorChua, S.
dc.contributor.authorShen, L.
dc.contributor.authorArulkumaran, S.
dc.date.accessioned2014-11-10T08:04:02Z
dc.date.available2014-11-10T08:04:02Z
dc.date.issued2004-04-15
dc.identifier.citationChong, Y.-S., Chua, S., Shen, L., Arulkumaran, S. (2004-04-15). Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery. European Journal of Obstetrics Gynecology and Reproductive Biology 113 (2) : 191-198. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejogrb.2003.09.011
dc.identifier.issn03012115
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107607
dc.description.abstractObjective: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes. Study design: Fifty women were given misoprostol 400μg either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters. Results: Uterine activity produced by oral solution misoprostol 400μg was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively). Conclusion: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects. © 2003 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ejogrb.2003.09.011
dc.sourceScopus
dc.subjectMisoprostol
dc.subjectPostpartum haemorrhage
dc.subjectRoute of administration
dc.subjectSide effects
dc.subjectUterotonic
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.ejogrb.2003.09.011
dc.description.sourcetitleEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.description.volume113
dc.description.issue2
dc.description.page191-198
dc.description.codenEOGRA
dc.identifier.isiut000220945100014
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