Please use this identifier to cite or link to this item:
|Title:||Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery||Authors:||Chong, Y.-S.
Route of administration
|Issue Date:||15-Apr-2004||Citation:||Chong, Y.-S., Chua, S., Shen, L., Arulkumaran, S. (2004-04-15). Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery. European Journal of Obstetrics Gynecology and Reproductive Biology 113 (2) : 191-198. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejogrb.2003.09.011||Abstract:||Objective: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes. Study design: Fifty women were given misoprostol 400μg either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters. Results: Uterine activity produced by oral solution misoprostol 400μg was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively). Conclusion: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects. © 2003 Elsevier Ireland Ltd. All rights reserved.||Source Title:||European Journal of Obstetrics Gynecology and Reproductive Biology||URI:||http://scholarbank.nus.edu.sg/handle/10635/107607||ISSN:||03012115||DOI:||10.1016/j.ejogrb.2003.09.011|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 20, 2020
WEB OF SCIENCETM
checked on Feb 20, 2020
checked on Feb 22, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.