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Title: Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus
Authors: Kong, K.O.
Tan, A.W.
Thong, B.Y.H.
Lian, T.Y.
Cheng, Y.K.
Teh, C.L.
Koh, E.T.
Chng, H.H.
Law, W.G.
Lau, T.C.
Leong, K.P.
Leung, B.P. 
Howe, H.S.
Keywords: Cytokine
Disease activity
Issue Date: Apr-2009
Citation: Kong, K.O., Tan, A.W., Thong, B.Y.H., Lian, T.Y., Cheng, Y.K., Teh, C.L., Koh, E.T., Chng, H.H., Law, W.G., Lau, T.C., Leong, K.P., Leung, B.P., Howe, H.S. (2009-04). Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus. Clinical and Experimental Immunology 156 (1) : 134-140. ScholarBank@NUS Repository.
Abstract: Our objective was to investigate the serum levels of interferon-inducible protein-10 (IP-10) in systemic lupus erythematosus (SLE) and their correlation with disease activity and organ manifestations. Serum IP-10 levels were assessed in 464 SLE patients and 50 healthy donors. Disease activity was assessed by the revised SLE Activity Measure, and the concomitant active organ manifestations, anti-ds DNA antibody titres, complement levels and erythrocyte sedimentation rates recorded. Peripheral blood mononuclear cell (PBMC) synthesis of IP-10 in SLE patients and controls was determined by in vitro cultures stimulated with mitogen or lipopolysaccharide. Elevated serum IP-10 levels were observed in SLE patients, which were significantly higher in the presence of active haematological and mucocutaneous manifestations. SLE PBMCs exhibited enhanced spontaneous IP-10 production in vitro. Serial IP-10 levels correlated with longitudinal change in SLE activity, even at low levels where anti-dsDNA antibody and complement levels remain unchanged. These data demonstrate that IP-10 levels are increased in SLE and serum IP-10 may represent a more sensitive marker for monitoring disease activity than standard serological tests. © 2009 British Society for Immunology.
Source Title: Clinical and Experimental Immunology
ISSN: 00099104
DOI: 10.1111/j.1365-2249.2009.03880.x
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