Please use this identifier to cite or link to this item: https://doi.org/10.1143/JJAP.45.1026
Title: Observation of hybridization on a DNA array by surface plasmon resonace imaging using Au nanoparticles
Authors: Nakamura, F.
Ito, M.
Manna, A.
Tamada, K. 
Hara, M.
Knoll, W. 
Keywords: Au nanoparticle
DNA array
Hybridization
Self-assembled monolayer
Surface plasmon resonance imaging
Issue Date: 8-Feb-2006
Citation: Nakamura, F., Ito, M., Manna, A., Tamada, K., Hara, M., Knoll, W. (2006-02-08). Observation of hybridization on a DNA array by surface plasmon resonace imaging using Au nanoparticles. Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers 45 (2 A) : 1026-1029. ScholarBank@NUS Repository. https://doi.org/10.1143/JJAP.45.1026
Abstract: To realize the sensitive detection of DNA hybridization, DNA-modified Au nanoparticles (DNA-AuNPs) containing single-and double-stranded portions were prepared. The hybridization of a target DNA using the DNA-AuNPs on a DNA self-assembled monolayer (DNA-SAM) was monitored in situ by surface plasmon resonance (SPR) imaging. A sandwich type hybridization (DNA-SAM/target DNA/DNA-AuNP) experiment was carried out in order to enhance the hybridization signal. SPR imaging results strongly indicate that the hybridization signal is enhanced several times compared to the case of target DNA hybridization. ©2006 The Japan Society of Applied Physics.
Source Title: Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
URI: http://scholarbank.nus.edu.sg/handle/10635/107148
ISSN: 00214922
DOI: 10.1143/JJAP.45.1026
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