Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.drudis.2009.03.012
Title: Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives
Authors: Ma, X.H. 
Zheng, C.J. 
Han, L.Y. 
Xie, B.
Jia, J.
Cao, Z.W.
Li, Y.X.
Chen, Y.Z. 
Issue Date: Jun-2009
Citation: Ma, X.H., Zheng, C.J., Han, L.Y., Xie, B., Jia, J., Cao, Z.W., Li, Y.X., Chen, Y.Z. (2009-06). Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. Drug Discovery Today 14 (11-12) : 579-588. ScholarBank@NUS Repository. https://doi.org/10.1016/j.drudis.2009.03.012
Abstract: Opinions about the therapeutic efficacy of medicinal herbs differ significantly. Some reported herbal efficacies at low doses of active ingredients suggest a need for investigating whether these are because of placebo or multi-ingredient synergistic effects. This review discusses the opinions, methods and outcomes of herbal synergism investigations and analyzes indications from 48 in vivo tests and 106 rigorous clinical trials. Analyses of ingredient-mediated interactions at molecular and pathway levels indicate multi-ingredient synergism in 27 of the 39 reported cases of herbal synergism with available ingredient information. Synergistic actions may be responsible for the therapeutic efficacy of a substantial number of herbal products and their mechanisms may be studied by analyzing ingredient-mediated molecular interactions and network regulation. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Drug Discovery Today
URI: http://scholarbank.nus.edu.sg/handle/10635/106709
ISSN: 13596446
DOI: 10.1016/j.drudis.2009.03.012
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