Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.critrevonc.2011.09.001
DC FieldValue
dc.titleNeuro-cognitive impairment in breast cancer patients: Pharmacological considerations
dc.contributor.authorCheung, Y.T.
dc.contributor.authorChui, W.K.
dc.contributor.authorChan, A.
dc.date.accessioned2014-10-29T02:03:44Z
dc.date.available2014-10-29T02:03:44Z
dc.date.issued2012-07
dc.identifier.citationCheung, Y.T., Chui, W.K., Chan, A. (2012-07). Neuro-cognitive impairment in breast cancer patients: Pharmacological considerations. Critical Reviews in Oncology/Hematology 83 (1) : 99-111. ScholarBank@NUS Repository. https://doi.org/10.1016/j.critrevonc.2011.09.001
dc.identifier.issn10408428
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106687
dc.description.abstractPost-chemotherapy cognitive impairment has been an issue of concern in cancer survivors. While most reviews are focused on patient-related factors, it is proposed that drug-related factors may also be determinants. The objective of this review is to study the relationship between the types and dose intensities of chemotherapy regimens on cognitive impairment in breast cancer patients through a systematic literature search.Eighteen prospective studies were selected. The types, dose intensities and durations of chemotherapy regimens received by subjects were compared against prevalence results obtained in individual studies. It was observed that the duration of impairment varied across different generations of chemotherapy regimens. Concurrent administration of multiple cytotoxic agents can lead to a synergistic decline on cognition.Current clinical evidence is insufficient to evaluate the relationship between the types, dose intensities of chemotherapy regimens and cognitive impairment. More investigation is needed to examine the role of pharmacological factors in chemotherapy-associated cognitive changes. © 2011 Elsevier Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.critrevonc.2011.09.001
dc.sourceScopus
dc.subjectBreast cancer
dc.subjectChemotherapy
dc.subjectCognitive function
dc.subjectNeurological
dc.subjectNeuropsychological
dc.subjectPsycho-oncology
dc.typeReview
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.critrevonc.2011.09.001
dc.description.sourcetitleCritical Reviews in Oncology/Hematology
dc.description.volume83
dc.description.issue1
dc.description.page99-111
dc.description.codenCCRHE
dc.identifier.isiut000306147100009
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