Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.critrevonc.2011.09.001
Title: Neuro-cognitive impairment in breast cancer patients: Pharmacological considerations
Authors: Cheung, Y.T.
Chui, W.K. 
Chan, A. 
Keywords: Breast cancer
Chemotherapy
Cognitive function
Neurological
Neuropsychological
Psycho-oncology
Issue Date: Jul-2012
Citation: Cheung, Y.T., Chui, W.K., Chan, A. (2012-07). Neuro-cognitive impairment in breast cancer patients: Pharmacological considerations. Critical Reviews in Oncology/Hematology 83 (1) : 99-111. ScholarBank@NUS Repository. https://doi.org/10.1016/j.critrevonc.2011.09.001
Abstract: Post-chemotherapy cognitive impairment has been an issue of concern in cancer survivors. While most reviews are focused on patient-related factors, it is proposed that drug-related factors may also be determinants. The objective of this review is to study the relationship between the types and dose intensities of chemotherapy regimens on cognitive impairment in breast cancer patients through a systematic literature search.Eighteen prospective studies were selected. The types, dose intensities and durations of chemotherapy regimens received by subjects were compared against prevalence results obtained in individual studies. It was observed that the duration of impairment varied across different generations of chemotherapy regimens. Concurrent administration of multiple cytotoxic agents can lead to a synergistic decline on cognition.Current clinical evidence is insufficient to evaluate the relationship between the types, dose intensities of chemotherapy regimens and cognitive impairment. More investigation is needed to examine the role of pharmacological factors in chemotherapy-associated cognitive changes. © 2011 Elsevier Ireland Ltd.
Source Title: Critical Reviews in Oncology/Hematology
URI: http://scholarbank.nus.edu.sg/handle/10635/106687
ISSN: 10408428
DOI: 10.1016/j.critrevonc.2011.09.001
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