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Title: Lipid-based nanoparticulate systems for the delivery of anti-cancer drug cocktails: Implications on pharmacokinetics and drug toxicities
Authors: Chiu, G.N.C. 
Wong, M.-Y.
Ling, L.-U.
Shaikh, I.M.
Tan, K.-B.
Chaudhury, A.
Tan, B.-J. 
Keywords: Cancer
Drug combination
Issue Date: Oct-2009
Citation: Chiu, G.N.C., Wong, M.-Y., Ling, L.-U., Shaikh, I.M., Tan, K.-B., Chaudhury, A., Tan, B.-J. (2009-10). Lipid-based nanoparticulate systems for the delivery of anti-cancer drug cocktails: Implications on pharmacokinetics and drug toxicities. Current Drug Metabolism 10 (8) : 861-874. ScholarBank@NUS Repository.
Abstract: The use of drug cocktails has become a widely adopted strategy in clinical cancer therapy. Cytotoxic drug cocktails are often administered based on maximum tolerated dose (MTD) of each agent, with the belief of achieving maximum cell kill through tolerable toxicity level. Yet, MTD administration may not have fully captured the therapeutic synergism that exists among the individual agents in the drug cocktail, as the response to a cocktail regimen, that is, whether the effect is synergistic or not, could be highly sensitive to the concentration ratios of the individual drugs at the site of action. It is important to realize that the inherently different pharmacokinetic profiles of the individual agents could have significant influence on the response to an anti-cancer drug cocktail by dictating the amount of the individual agents reaching the tumor site and therefore the concentration ratios. Furthermore, the individual agents may have unfavorable pharmacokinetic interactions that add to the difficulty in determining the therapeutic and/or toxicological effects of the drug cocktail. In this review, we will focus on how lipid-based nanoparticulate systems could address the above issues associated with anti-cancer drug cocktails. Specifically, we will highlight the use of liposome systems as the means to control and coordinate the delivery of various anti-cancer drug cocktails, encompassing conventional chemotherapeutics, chemosensitizing agents and molecularly targeted agents. © 2009 Bentham Science Publishers Ltd.
Source Title: Current Drug Metabolism
ISSN: 13892002
DOI: 10.2174/138920009790274531
Appears in Collections:Staff Publications

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