Please use this identifier to cite or link to this item:
|Title:||Antimicrobial activity of the medicinal mushroom Ganoderma||Authors:||Gao, Y.
|Issue Date:||Apr-2005||Citation:||Gao, Y., Tang, W., Gao, H.E., Chan, E., Lan, J., Li, X., Zhou, S. (2005-04). Antimicrobial activity of the medicinal mushroom Ganoderma. Food Reviews International 21 (2) : 211-229. ScholarBank@NUS Repository. https://doi.org/10.1081/FRI-200051893||Abstract:||Over the past century, a number of synthetic antimicrobial agents have been discovered and developed, but drug resistance and toxicity are still the major hindrances to gaining successful therapeutic outcomes in many instances. Herbal medicines may represent a safe and useful supplement to existing chemotherapeutic therapies for the management of infectious diseases. Ganoderma has traditionally been used to treat chronic infectious diseases, such as chronic hepatitis and bronchitis in Asia, when it is administered alone or more often in combination with chemotherapeutic agents. Preclinical (in vitro and in vivo animal) studies indicate that Ganoderma exhibits a broad spectrum of antibacterial and antiviral activities, whereas data in human beings are scanty. Polysaccharides or triterpenoids from Ganoderma showed activities against Herpes simple virus, Hepatitis B virus, HIV, and Epstein-Barr virus in vitro or in animal models. Ganoderma species also contain antibacterial constituents inhibiting gram-positive and/or gram-negative bacteria in vitro. However, it is difficult to extrapolate these findings to humans, as most of these preclinical studies were conducted under optimized conditions with the use of high doses of Ganoderma components. A double-blind, randomized, placebo-controlled clinical study indicated that treatment of hepatitis B patients with G. lucidum polysaccharides at 5400 mg/ day for 12 weeks resulted in significantly decreased serum HBV DNA and hepatitis B e antigen (HbeAg) levels. The mechanisms for the antimicrobial and antiviral activities of Ganoderma are largely undefined. Currently available data do not support the use of Ganoderma as an antibiotic, but it may play an adjunct role for the management of bacterial and viral infection. Further studies are needed in humans. Copyright © Taylor & Francis Inc.||Source Title:||Food Reviews International||URI:||http://scholarbank.nus.edu.sg/handle/10635/106613||ISSN:||87559129||DOI:||10.1081/FRI-200051893|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 16, 2019
WEB OF SCIENCETM
checked on Jul 16, 2019
checked on Jun 14, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.