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Title: Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates
Authors: Dinish, U.S.
Fu, C.Y.
Agarwal, A.
Thoniyot, P.
Olivo, M. 
Keywords: deep UV lithography
glucose sensing
self assembled monolayer
Surface Enhanced Raman Scattering
Issue Date: 2009
Citation: Dinish, U.S., Fu, C.Y., Agarwal, A., Thoniyot, P., Olivo, M. (2009). Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates. Proceedings of SPIE - The International Society for Optical Engineering 7397 : -. ScholarBank@NUS Repository.
Abstract: Surface Enhanced Raman Scattering (SERS) technique is used as an indispensable and sensitive modality for bio-sensing due to its ability to distinguish the analyte molecules based on their distinct 'fingerprint' spectra. One of the most promising SERS substrates for biosensing was fabricated by coating noble metal film over orderly packed nanospheres. However, the major challenge in developing such a sensor is to achieve reproducible SERS substrate. Here, we report a new class of SERS substrate with ordered 3D nanostructures fabricated on silicon wafer by deep UV lithography technique followed by bi-metallic coating of silver and gold. Compared to the substrate fabricated by conventional nanosphere lithography, this approach allows better control of the nanostructures, which in turn gives uniform surface roughness for the metal film to provide adequate SERS enhancement with high reproducibility. Significance of this substrate for biomedical application was demonstrated by glucose sensing under physiologically relevant conditions. Partitioning and localization of glucose molecules within the first few nanometers of active SERS substrate was achieved by a self assembled monolayer (SAM) on the surface of substrate. © 2009 Copyright SPIE - The International Society for Optical Engineering.
Source Title: Proceedings of SPIE - The International Society for Optical Engineering
ISBN: 9780819476876
ISSN: 0277786X
DOI: 10.1117/12.827228
Appears in Collections:Staff Publications

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