Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.890076
DC FieldValue
dc.titleDevelopment of Au/Ag substrate with alternating nanosphere array for SERS-based biosensing
dc.contributor.authorFu, C.Y.
dc.contributor.authorDinish, U.S.
dc.contributor.authorKho, K.W.
dc.contributor.authorWenda, D.G.
dc.contributor.authorOlivo, M.
dc.date.accessioned2014-10-29T02:01:13Z
dc.date.available2014-10-29T02:01:13Z
dc.date.issued2011
dc.identifier.citationFu, C.Y., Dinish, U.S., Kho, K.W., Wenda, D.G., Olivo, M. (2011). Development of Au/Ag substrate with alternating nanosphere array for SERS-based biosensing. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8090 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.890076
dc.identifier.isbn9780819486875
dc.identifier.issn16057422
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106523
dc.description.abstractNanostructure substrates are effective biosensor to spectrally differentiate multiple compounds by Surface-enhanced Raman scattering (SERS). Metal film over nanosphere (MFON) has been demonstrated to exhibit reproducible and predictable Raman enhancement. MFON can be fabricated using an economical process in which polystyrene (PS) nanospheres are self-assembled on a planar solid supports and then followed by metal coating. In this work, we investigate the MFON substrates with bimetallic coating to combine the optical-enhancing and stability features from Ag and Au layers. The SERS responses are then quantified from the resultant bimetallic structures with 2-Naphthalenethiol. We show that the bimetallic substrate of optimal Au/Ag thickness ratio renders SERS enhancement and stability exceeding those of the Au-coated MFON. Compared to Au array, the bimetallic substrate exhibits quasi-bimetallic nanoparticles of surpassing SERS (2.5 times) with enhancement factor determined to be 2×107. As a proof-of-concept for biosensing in microfluidics, SERS nanotag was prepared and tested on the optimized BMFON. In addition, we propose a fabrication scheme to construct MFON with alternating sizes (100nm and 400nm) of nanosphere. At optimal proportional amount, the 100nm-spheres were packed within the gaps between the 400nm-spheres. The resultant morphology renders additional nanogaps that could possibly lead to increment in SERS enhancement. © 2011 SPIE-OSA.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1117/12.890076
dc.sourceScopus
dc.subjectBimetallic
dc.subjectDNA
dc.subjectMicrofluidics
dc.subjectNanogap
dc.subjectNanotag
dc.subjectSERS
dc.typeConference Paper
dc.contributor.departmentPHARMACY
dc.description.doi10.1117/12.890076
dc.description.sourcetitleProgress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.description.volume8090
dc.description.page-
dc.identifier.isiut000293625400008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

1
checked on Nov 19, 2021

Page view(s)

121
checked on Nov 18, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.