Please use this identifier to cite or link to this item:
https://doi.org/10.1615/IntJMedMushr.v8.i4.30
DC Field | Value | |
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dc.title | Water-soluble polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) alleviate the dose-limiting toxicities of irinotecan (CPT-11) | |
dc.contributor.author | Hu, Z. | |
dc.contributor.author | Chen, X. | |
dc.contributor.author | Yang, X. | |
dc.contributor.author | Gao, Y. | |
dc.contributor.author | Zhou, S. | |
dc.date.accessioned | 2014-10-29T02:01:04Z | |
dc.date.available | 2014-10-29T02:01:04Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Hu, Z.,Chen, X.,Yang, X.,Gao, Y.,Zhou, S. (2006). Water-soluble polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) alleviate the dose-limiting toxicities of irinotecan (CPT-11). International Journal of Medicinal Mushrooms 8 (4) : 321-327. ScholarBank@NUS Repository. <a href="https://doi.org/10.1615/IntJMedMushr.v8.i4.30" target="_blank">https://doi.org/10.1615/IntJMedMushr.v8.i4.30</a> | |
dc.identifier.issn | 15219437 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/106509 | |
dc.description.abstract | Ganoderma lucidum extracts attenuated cisplatin-induced nausea and vomiting in rats. The clinical use of irinotecan (CPT-11) is hindered by dose-limiting diarrhea and myelosuppression. This study aimed to investigate whether a combination of G. lucidum polysaccharides (25 mg/kg by gavage) modulated the toxicities of CPT-11 in rats. The rat toxicity model was constructed by treatment of CPT-11 at 60 mg/kg/day by intravenous injection. Incidence of acute and delayed-onset diarrhea, blood cell counts, and body weight were monitored throughout the study. Administration of CPT-11 and a control vehicle (sterile water) for four days to rats induced a significant decrease in neutrophils and lymphocytes counts, body weight loss, and severe acute and delayed-onset diarrhea. These toxicities were suppressed when CPT-11 was combined with G. lucidum polysaccharides. Further study is needed to explore the mechanisms for the protective effect of G. lucidum polysaccharides against CPT-11 toxicity. © 2006 by Begell House, Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1615/IntJMedMushr.v8.i4.30 | |
dc.source | Scopus | |
dc.subject | Diarrhea | |
dc.subject | Ganoderma lucidum | |
dc.subject | Irinotecan (CPT-11) | |
dc.subject | Myelosuppression | |
dc.subject | Polysaccharide | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.1615/IntJMedMushr.v8.i4.30 | |
dc.description.sourcetitle | International Journal of Medicinal Mushrooms | |
dc.description.volume | 8 | |
dc.description.issue | 4 | |
dc.description.page | 321-327 | |
dc.description.coden | IMMUF | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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