Please use this identifier to cite or link to this item:
Title: Water-soluble polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) alleviate the dose-limiting toxicities of irinotecan (CPT-11)
Authors: Hu, Z.
Chen, X.
Yang, X.
Gao, Y.
Zhou, S. 
Keywords: Diarrhea
Ganoderma lucidum
Irinotecan (CPT-11)
Issue Date: 2006
Citation: Hu, Z.,Chen, X.,Yang, X.,Gao, Y.,Zhou, S. (2006). Water-soluble polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) alleviate the dose-limiting toxicities of irinotecan (CPT-11). International Journal of Medicinal Mushrooms 8 (4) : 321-327. ScholarBank@NUS Repository.
Abstract: Ganoderma lucidum extracts attenuated cisplatin-induced nausea and vomiting in rats. The clinical use of irinotecan (CPT-11) is hindered by dose-limiting diarrhea and myelosuppression. This study aimed to investigate whether a combination of G. lucidum polysaccharides (25 mg/kg by gavage) modulated the toxicities of CPT-11 in rats. The rat toxicity model was constructed by treatment of CPT-11 at 60 mg/kg/day by intravenous injection. Incidence of acute and delayed-onset diarrhea, blood cell counts, and body weight were monitored throughout the study. Administration of CPT-11 and a control vehicle (sterile water) for four days to rats induced a significant decrease in neutrophils and lymphocytes counts, body weight loss, and severe acute and delayed-onset diarrhea. These toxicities were suppressed when CPT-11 was combined with G. lucidum polysaccharides. Further study is needed to explore the mechanisms for the protective effect of G. lucidum polysaccharides against CPT-11 toxicity. © 2006 by Begell House, Inc.
Source Title: International Journal of Medicinal Mushrooms
ISSN: 15219437
DOI: 10.1615/IntJMedMushr.v8.i4.30
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Aug 3, 2022

Page view(s)

checked on Aug 4, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.