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Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/106468
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dc.titleTransport of thalidomide by the human intestinal Caco-2 monolayers
dc.contributor.authorZhou, S.
dc.contributor.authorLi, Y.
dc.contributor.authorKestell, P.
dc.contributor.authorSchafer, P.
dc.contributor.authorChan, E.
dc.contributor.authorPaxton, J.W.
dc.date.accessioned2014-10-29T02:00:32Z
dc.date.available2014-10-29T02:00:32Z
dc.date.issued2005-01
dc.identifier.citationZhou, S.,Li, Y.,Kestell, P.,Schafer, P.,Chan, E.,Paxton, J.W. (2005-01). Transport of thalidomide by the human intestinal Caco-2 monolayers. European Journal of Drug Metabolism and Pharmacokinetics 30 (1-2) : 49-61. ScholarBank@NUS Repository.
dc.identifier.issn03787966
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106468
dc.description.abstractStudies in patients have indicated that the oral absorption of thalidomide is considerably variable at high doses (>200 mg/day). The aim of this study was to investigate the transport of racemic thalidomide using human colon cancer cell line (Caco-2) monolayers, which have been widely used to investigate drug permeability. A typical 21-day protocol was used to prepare Caco-2 monolayers. Thalidomide was determined by a validated high performance liquid chromatography method with ultraviolet detection. The integrity of Caco-2 monolayer was confirmed when the transepithelial electrical resistance (TEER) exceeded 300 Ω · cm2, and the leakage of 14C-manitol was
dc.sourceScopus
dc.subjectCaco-2
dc.subjectIntestinal
dc.subjectPermeability
dc.subjectThalidomide
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.sourcetitleEuropean Journal of Drug Metabolism and Pharmacokinetics
dc.description.volume30
dc.description.issue1-2
dc.description.page49-61
dc.description.codenEJDPD
dc.identifier.isiutNOT_IN_WOS
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