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Title: Stability of phenoxybenzamine hydrochloride in various vehicles
Authors: Lim, L.-Y. 
Tan, L.-L.
Chan, E.W.Y. 
Yow, K.-L.
Chan, S.-Y. 
Ho, P.C.L. 
Keywords: Capsules Citric acid
Phenoxybenzamine hydrochloride
Propylene glycol
Sympatholytic agents
Issue Date: 15-Sep-1997
Citation: Lim, L.-Y.,Tan, L.-L.,Chan, E.W.Y.,Yow, K.-L.,Chan, S.-Y.,Ho, P.C.L. (1997-09-15). Stability of phenoxybenzamine hydrochloride in various vehicles. American Journal of Health-System Pharmacy 54 (18) : 2073-2078. ScholarBank@NUS Repository.
Abstract: The stability of phenoxybenzamine hydrochloride in various oral liquids was studied. Phenoxybenzamine hydrochloride powder or capsules were combined with various vehicles to prepare 10-mL formulations with a drug concentration of 2 mg/mL and a 20-mL stock solution containing 10 mg/mL. All formulations were prepared in triplicate and stored at 4 °C. A 1.0-mL sample of each of the g mg/mL formulations was withdrawn on days 0, 1, 2, 3, and 4, and samples of selected formulations were taken on days 7 and 10. Samples of the stock solution were withdrawn on days 0, 2, 4, 7, 10, 14, and 30. All samples were analyzed by highperformance liquid chromatography. Phenoxybenzamine hydrochloride 2 mg/mL was stable for a longer time in 1% propylene glycol. 0.15% citric acid, and water than in a similar vehicle in which syrup was used in place of water. The concentrations of the drug in both the 10-mg/mL stock solution and stock solutions diluted to 2 mg/mL were >90% of the initial drug concentration for 30 days. Phenoxybenzamine hydrochloride 2 mg/mL in 1% propylene glycol and 0.15% citric acid in distilled water was stable for 7 days at 4 °C. A stock solution of phenoxybenzamine hydrochloride 10 mg/mL in propylene glycol was stable for 30 days at 4 °C and, after dilution with 66.7% sucrose in distilled water to a concentration of 2 mg/mL, for up to one hour at 4 °C.
Source Title: American Journal of Health-System Pharmacy
ISSN: 10792082
Appears in Collections:Staff Publications

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