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Title: Stability of cefazolin sodium eye drops
Authors: How, T.H.
Loo, W.Y.
Yow, K.L.
Lim, L.Y. 
Chan, E.W. 
Ho, P.C. 
Chan, S.Y. 
Issue Date: 1998
Citation: How, T.H., Loo, W.Y., Yow, K.L., Lim, L.Y., Chan, E.W., Ho, P.C., Chan, S.Y. (1998). Stability of cefazolin sodium eye drops. Journal of Clinical Pharmacy and Therapeutics 23 (1) : 41-47. ScholarBank@NUS Repository.
Abstract: Objective: Assessing the stability of cefazolin sodium in preservative-free and preservative-containing eye drops. Method: Extemporaneous formulations of eye drops were prepared from a commercially-available parenteral product of cefazolin sodium: eye drops 'A' contained 50 mg/ml of cefazolin sodium in 0.45% w/v sodium chloride solution, and eye drops 'B' contained 50 mg/ml, 0.005% w/v thiomersal and 1% w/v glycerol in water-for-injection. Cefazolin sodium concentrations in these eye drops were monitored by a stability-indicating HPLC assay method. Measurements of pH and osmolality, as well as tests for microbial contamination, were conducted. Results: The eye drops stored at 4°C were stable for 42 days with minimal changes in pH and osmolality, but eye drops stored at room temperature were only stable for a few days with greater increments in pH and osmolality. None of the samples cultured had bacterial or fungal growth after 7 days of incubation. Conclusion: Extemporaneously prepared formulations of cefazolin are unstable at room temperature and should be stored in a refrigerator.
Source Title: Journal of Clinical Pharmacy and Therapeutics
ISSN: 02694727
DOI: 10.1046/j.1365-2710.1998.00136.x
Appears in Collections:Staff Publications

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