Please use this identifier to cite or link to this item:
|Title:||Stability of cefazolin sodium eye drops||Authors:||How, T.H.
|Issue Date:||1998||Citation:||How, T.H., Loo, W.Y., Yow, K.L., Lim, L.Y., Chan, E.W., Ho, P.C., Chan, S.Y. (1998). Stability of cefazolin sodium eye drops. Journal of Clinical Pharmacy and Therapeutics 23 (1) : 41-47. ScholarBank@NUS Repository. https://doi.org/10.1046/j.1365-2710.1998.00136.x||Abstract:||Objective: Assessing the stability of cefazolin sodium in preservative-free and preservative-containing eye drops. Method: Extemporaneous formulations of eye drops were prepared from a commercially-available parenteral product of cefazolin sodium: eye drops 'A' contained 50 mg/ml of cefazolin sodium in 0.45% w/v sodium chloride solution, and eye drops 'B' contained 50 mg/ml, 0.005% w/v thiomersal and 1% w/v glycerol in water-for-injection. Cefazolin sodium concentrations in these eye drops were monitored by a stability-indicating HPLC assay method. Measurements of pH and osmolality, as well as tests for microbial contamination, were conducted. Results: The eye drops stored at 4°C were stable for 42 days with minimal changes in pH and osmolality, but eye drops stored at room temperature were only stable for a few days with greater increments in pH and osmolality. None of the samples cultured had bacterial or fungal growth after 7 days of incubation. Conclusion: Extemporaneously prepared formulations of cefazolin are unstable at room temperature and should be stored in a refrigerator.||Source Title:||Journal of Clinical Pharmacy and Therapeutics||URI:||http://scholarbank.nus.edu.sg/handle/10635/106358||ISSN:||02694727||DOI:||10.1046/j.1365-2710.1998.00136.x|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 15, 2020
WEB OF SCIENCETM
checked on Jan 8, 2020
checked on Jan 18, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.