Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.bbrc.2007.12.175
DC Field | Value | |
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dc.title | S-Allylcysteine reduces breast tumor cell adhesion and invasion | |
dc.contributor.author | Gapter, L.A. | |
dc.contributor.author | Yuin, O.Z. | |
dc.contributor.author | Ng, K.-y. | |
dc.date.accessioned | 2014-10-29T01:58:18Z | |
dc.date.available | 2014-10-29T01:58:18Z | |
dc.date.issued | 2008-03-07 | |
dc.identifier.citation | Gapter, L.A., Yuin, O.Z., Ng, K.-y. (2008-03-07). S-Allylcysteine reduces breast tumor cell adhesion and invasion. Biochemical and Biophysical Research Communications 367 (2) : 446-451. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2007.12.175 | |
dc.identifier.issn | 0006291X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/106321 | |
dc.description.abstract | Previous studies show that aqueous garlic extract and its derivatives (e.g. S-allylcysteine [SAC]) prevent carcinogen-induced breast tumorigenesis. However, investigations testing the effect of SAC on later stages of breast tumorigenesis and/or metastasis have produced mixed results. Here we show that SAC significantly reduced anchorage-dependent and -independent growth of MDA-MB-231 breast tumor cells in a dose- and time-dependent fashion, and sub-lethal SAC-treatment altered mammary tumor cell adhesion and invasion through components of the extracellular matrix. We provide evidence to suggest increased expression of E-cadherin and reduced MMP-2 expression and activity are partially responsible for inhibition of mammary tumor cell invasion by SAC. Because E-cadherin and MMP-2 are important in cancer metastasis, these results suggest a link between SAC induction of E-cadherin and reduction of MMP2 activity with the inhibition of cell motility and invasion; thus providing evidence that events leading to breast cancer metastasis are repressed by sub-lethal SAC-treatment. © 2007 Elsevier Inc. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2007.12.175 | |
dc.source | Scopus | |
dc.subject | Breast cancer | |
dc.subject | E-cadherin | |
dc.subject | Garlic | |
dc.subject | Matrix metalloprotease | |
dc.subject | MDA-MB-231 | |
dc.subject | Metastasis | |
dc.subject | MMP | |
dc.subject | S-Allylcysteine | |
dc.subject | SAC | |
dc.subject | Tumor growth | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.1016/j.bbrc.2007.12.175 | |
dc.description.sourcetitle | Biochemical and Biophysical Research Communications | |
dc.description.volume | 367 | |
dc.description.issue | 2 | |
dc.description.page | 446-451 | |
dc.description.coden | BBRCA | |
dc.identifier.isiut | 000252834700033 | |
Appears in Collections: | Staff Publications |
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