Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/106230
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dc.titlePopulation pharmacokinetics of phenytoin in Singapore Chinese
dc.contributor.authorChan, E.
dc.contributor.authorTi, T.Y.
dc.contributor.authorLee, H.S.
dc.date.accessioned2014-10-29T01:57:03Z
dc.date.available2014-10-29T01:57:03Z
dc.date.issued1990-08
dc.identifier.citationChan, E., Ti, T.Y., Lee, H.S. (1990-08). Population pharmacokinetics of phenytoin in Singapore Chinese. European Journal of Clinical Pharmacology 39 (2) : 177-181. ScholarBank@NUS Repository.
dc.identifier.issn00316970
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106230
dc.description.abstractThe pharmacokinetics of phenytoin was studied in 66 epileptic Chinese children and adults. The data were analysed by the population approach, using the non-linear mixed effect model, in the MULTI (ELS) program. There was no age or gender-related effect on either the apparent maximum elimination rate (kmax) or Michaelis-Menten constant (KM). Kmax was related to body weight 0.656. The population pharmacokinetics was similar in children and adults. Kmax and KM were estimated to be 30.72 mg·kg-0.656 day-1 and 2.307 mg·l-1, respectively. Kmax was higher than reported values, and KM was comparable to that reported in a study in Japanese, but was much lower than that reported in studies of European patients. The inter-individual variability of KM (CV 65.58%) was substantially higher than that of kmax (CV 28.49%), and the residual (intra-individual) variability was found 21.33% (CV). © 1990 Springer-Verlag.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/BF00280055
dc.sourceScopus
dc.subjectchildren and adults
dc.subjectChinese epileptics
dc.subjectpharmacogenetics
dc.subjectPhenytoin
dc.subjectpopulation pharmacokinetics
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.sourcetitleEuropean Journal of Clinical Pharmacology
dc.description.volume39
dc.description.issue2
dc.description.page177-181
dc.description.codenEJCPA
dc.identifier.isiutA1990DV45200016
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