Please use this identifier to cite or link to this item:
Title: Polyethyleneimine-modified pectin beads for colon-specific drug delivery: In vitro and in vivo implications
Authors: Das, S.
Chaudhury, A.
Ng, K.-Y. 
Keywords: bead
Issue Date: Jun-2011
Citation: Das, S., Chaudhury, A., Ng, K.-Y. (2011-06). Polyethyleneimine-modified pectin beads for colon-specific drug delivery: In vitro and in vivo implications. Journal of Microencapsulation 28 (4) : 268-279. ScholarBank@NUS Repository.
Abstract: Calcium-pectinate (Ca-pectinate) beads have shown immense potential as colon-specific drug carrier. However, Ca-pectinate itself is unable to prevent its swelling/degradation in the upper gastro-intestinal (GI) conditions. Hence, polyethyleneimine (PEI) was added in the cross-linking solution to strengthen the Ca-pectinate network. Resveratrol was used as a model drug due to its promising therapeutic activity towards several colonic diseases. Beads were prepared by varying cross-linking solution pH and other formulation variables. The effects of these formulation variables were investigated on the bead's characteristics. Furthermore, surface morphology, drug-polymer interaction, stability, and in vivo pharmacokinetic study of the optimized formulation were performed. The optimized PEI-modified beads prevented drug release in the upper GI conditions, while released the drug in simulated colonic fluid. Furthermore, in vivo pharmacokinetics studies in rats demonstrated delayed appearance of drug in blood after oral administration. The optimized Ca-pectinate beads demonstrated both in vitro and in vivo colon-specific drug release. © 2011 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Source Title: Journal of Microencapsulation
ISSN: 02652048
DOI: 10.3109/02652048.2011.559284
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.