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https://doi.org/10.1016/j.bbrc.2006.04.110
Title: | Pim-1 kinase expression during murine mammary development | Authors: | Gapter, L.A. Magnuson, N.S. Ng, K.-y. Hosick, H.L. |
Keywords: | Breast Growth and development Kinase Mammary cell line P21CIP/Waf1 Pim-1 Progesterone |
Issue Date: | 7-Jul-2006 | Citation: | Gapter, L.A., Magnuson, N.S., Ng, K.-y., Hosick, H.L. (2006-07-07). Pim-1 kinase expression during murine mammary development. Biochemical and Biophysical Research Communications 345 (3) : 989-997. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2006.04.110 | Abstract: | Pim-1 kinase phosphorylates substrates whose activities are linked to proliferation, survival, differentiation, and apoptosis. Although pim-1 is induced by hormones and cytokines, the hormonal control and contribution of Pim-1 to mammary gland development have not been evaluated. We examined Pim-1 expression in mammary cell lines, investigated whether Pim-1 levels could be altered in breast epithelia by mammogenic hormones, and evaluated Pim-1 expression during mammary development. We found that Pim-1 was elevated in most mammary carcinoma cell lines and progesterone increased Pim-1 protein to some extent in non-tumorigenic mammary epithelia. Pim-1 expression in situ was consistent with the documented profile of progesterone activity in mouse mammary glands. Pim-1 nuclear localization correlated with cytoplasmic distribution for its substrate, p21CIP/Waf1, and we found that Pim-1 and p21 associate in vitro. Our results suggest that Pim-1 expression may be regulated by progesterone during mammary development and Pim-1 associates with p21 in mammary epithelial cells. © 2006 Elsevier Inc. All rights reserved. | Source Title: | Biochemical and Biophysical Research Communications | URI: | http://scholarbank.nus.edu.sg/handle/10635/106222 | ISSN: | 0006291X | DOI: | 10.1016/j.bbrc.2006.04.110 |
Appears in Collections: | Staff Publications |
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