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|Title:||Pim-1 kinase expression during murine mammary development||Authors:||Gapter, L.A.
Growth and development
Mammary cell line
|Issue Date:||7-Jul-2006||Citation:||Gapter, L.A., Magnuson, N.S., Ng, K.-y., Hosick, H.L. (2006-07-07). Pim-1 kinase expression during murine mammary development. Biochemical and Biophysical Research Communications 345 (3) : 989-997. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2006.04.110||Abstract:||Pim-1 kinase phosphorylates substrates whose activities are linked to proliferation, survival, differentiation, and apoptosis. Although pim-1 is induced by hormones and cytokines, the hormonal control and contribution of Pim-1 to mammary gland development have not been evaluated. We examined Pim-1 expression in mammary cell lines, investigated whether Pim-1 levels could be altered in breast epithelia by mammogenic hormones, and evaluated Pim-1 expression during mammary development. We found that Pim-1 was elevated in most mammary carcinoma cell lines and progesterone increased Pim-1 protein to some extent in non-tumorigenic mammary epithelia. Pim-1 expression in situ was consistent with the documented profile of progesterone activity in mouse mammary glands. Pim-1 nuclear localization correlated with cytoplasmic distribution for its substrate, p21CIP/Waf1, and we found that Pim-1 and p21 associate in vitro. Our results suggest that Pim-1 expression may be regulated by progesterone during mammary development and Pim-1 associates with p21 in mammary epithelial cells. © 2006 Elsevier Inc. All rights reserved.||Source Title:||Biochemical and Biophysical Research Communications||URI:||http://scholarbank.nus.edu.sg/handle/10635/106222||ISSN:||0006291X||DOI:||10.1016/j.bbrc.2006.04.110|
|Appears in Collections:||Staff Publications|
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