Please use this identifier to cite or link to this item: https://doi.org/10.1248/bpb.24.1373
Title: Phenolic compounds of Chromolaena adorata protect cultured skin cells from oxidative damage: Implication for cutaneous wound healing
Authors: Phan, T.-T.
Wang, L. 
See, P.
Grayer, R.J.
Chan, S.-Y. 
Lee, S.T.
Keywords: Antioxidant
Chromolaena odorata extract
Oxidative damage
Wound healing
Issue Date: 2001
Citation: Phan, T.-T., Wang, L., See, P., Grayer, R.J., Chan, S.-Y., Lee, S.T. (2001). Phenolic compounds of Chromolaena adorata protect cultured skin cells from oxidative damage: Implication for cutaneous wound healing. Biological and Pharmaceutical Bulletin 24 (12) : 1373-1379. ScholarBank@NUS Repository. https://doi.org/10.1248/bpb.24.1373
Abstract: Extracts from the leaves of Chromolaena odorata have been shown to be beneficial for treatment of wounds. The crude ethanol extract of the plant had been demonstrated to be a powerful antioxidant to protect fibroblasts and keratinocytes in vitro. In this study, the most active compounds were fractionated and identified from the crude extract using liquid chromatography coupled with UV spectroscopy and mass spectrometry. The antioxidant effects of purified fractions on cultured fibroblasts and keratinocytes were investigated using colorimetric and lactate hydrogenase release assay. The results showed that the phenolic acids present (protocatechuic, p-hydroxybenzoic, p-coumaric, ferulic and vanillic acids) and complex mixtures of lipophilic flavonoid aglycones (flavanones, flavonols, flavones and chalcones) were major and powerful antioxidants to protect cultured skin cells against oxidative damage. In conclusion, the extract from C. odorata contains a mixture of powerful antioxidant compounds that may be one of potential mechanism contributing to enhanced wound healing.
Source Title: Biological and Pharmaceutical Bulletin
URI: http://scholarbank.nus.edu.sg/handle/10635/106215
ISSN: 09186158
DOI: 10.1248/bpb.24.1373
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