Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cplett.2009.04.009
Title: Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations
Authors: Guo, X.D.
Tan, J.P.K.
Zhang, L.J.
Khan, M.
Liu, S.Q. 
Yang, Y.Y.
Qian, Y.
Issue Date: 12-May-2009
Citation: Guo, X.D., Tan, J.P.K., Zhang, L.J., Khan, M., Liu, S.Q., Yang, Y.Y., Qian, Y. (2009-05-12). Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations. Chemical Physics Letters 473 (4-6) : 336-342. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cplett.2009.04.009
Abstract: DPD simulations were employed to study the phase behavior of paclitaxel loaded PEO11-b-PLLA9 in water and N,N-Dimethylformamide. Different ordered structures were observed in water-rich solvents. All the structures were greatly affected by solvents compositions. By varying the fractions of each component, a phase diagram of paclitaxel loaded PEO11-b-PLLA9 in water and DMF was mapped. For all ordered structures, bicontinuous, lamella, rod, and spherical structures with different sizes could be easily observed for their wide distribution in the phase diagram. While the HPL, dumbbell, and spherical structures with uniform size were difficult to be obtained, due to their narrow distribution. © 2009 Elsevier B.V. All rights reserved.
Source Title: Chemical Physics Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/106213
ISSN: 00092614
DOI: 10.1016/j.cplett.2009.04.009
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