Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11468-012-9438-1
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dc.titleOptimized Synthesis of PEG-Encapsulated Gold Nanorods for Improved Stability and Its Application in OCT Imaging with Enhanced Contrast
dc.contributor.authorDinish, U.S.
dc.contributor.authorGoh, D.
dc.contributor.authorFu, C.Y.
dc.contributor.authorBhuvaneswari, R.
dc.contributor.authorSun, W.
dc.contributor.authorOlivo, M.
dc.date.accessioned2014-10-29T01:56:29Z
dc.date.available2014-10-29T01:56:29Z
dc.date.issued2013-06
dc.identifier.citationDinish, U.S., Goh, D., Fu, C.Y., Bhuvaneswari, R., Sun, W., Olivo, M. (2013-06). Optimized Synthesis of PEG-Encapsulated Gold Nanorods for Improved Stability and Its Application in OCT Imaging with Enhanced Contrast. Plasmonics 8 (2) : 591-598. ScholarBank@NUS Repository. https://doi.org/10.1007/s11468-012-9438-1
dc.identifier.issn15571955
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106188
dc.description.abstractGold nanorods (GNRs) are synthesized with a surfactant template, which often poses toxicity issues for biomedical applications. In addition, blue shift of longitudinal surface plasmon resonance (LSPR) peak of GNR is an inherent problem that needs to be addressed for time-course studies. In this work, we resolve these issues by optimizing the encapsulation of GNRs with polyethylene glycol (PEG) where biocompatibility is improved by ∼20 % and blue shift over a period of 8 days is reduced from 20 nm in the case of CTAB-GNR to 2 nm for PEG-encapsulated GNR. The encapsulated GNRs were then bioconjugated for targeted dark-field imaging of cancer cells. As an application, we also demonstrate the contrast-enhancing capability of GNRs in optical coherence tomography (OCT) imaging of tumor xenograft where the LSPR closely matches the OCT excitation wavelength. Our study proves that incorporating GNRs enhances the contrast of tumor tissue interfaces along with a considerable broadening in OCT depth profile by six times. © 2012 Springer Science+Business Media, LLC.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s11468-012-9438-1
dc.sourceScopus
dc.subjectContrast enhancement
dc.subjectCytotoxicity
dc.subjectGold nanorods
dc.subjectLongitudinal surface plasmon resonance
dc.subjectOCT imaging
dc.subjectPEG encapsulation
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1007/s11468-012-9438-1
dc.description.sourcetitlePlasmonics
dc.description.volume8
dc.description.issue2
dc.description.page591-598
dc.identifier.isiut000320445700054
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