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Title: Optimization of process parameters for a quasi-continuous tablet coating system using design of experiments
Authors: Cahyadi, C.
Heng, P.W.S. 
Chan, L.W. 
Keywords: coat quality
design of experiments
process optimization
supercell coater
tablet coating
Issue Date: Mar-2011
Citation: Cahyadi, C., Heng, P.W.S., Chan, L.W. (2011-03). Optimization of process parameters for a quasi-continuous tablet coating system using design of experiments. AAPS PharmSciTech 12 (1) : 119-131. ScholarBank@NUS Repository.
Abstract: The aim of this study was to identify and optimize the critical process parameters of the newly developed Supercell quasi-continuous coater for optimal tablet coat quality. Design of experiments, aided by multivariate analysis techniques, was used to quantify the effects of various coating process conditions and their interactions on the quality of film-coated tablets. The process parameters varied included batch size, inlet temperature, atomizing pressure, plenum pressure, spray rate and coating level. An initial screening stage was carried out using a 26-1(IV) fractional factorial design. Following these preliminary experiments, optimization study was carried out using the Box-Behnken design. Main response variables measured included drug-loading efficiency, coat thickness variation, and the extent of tablet damage. Apparent optimum conditions were determined by using response surface plots. The process parameters exerted various effects on the different response variables. Hence, trade-offs between individual optima were necessary to obtain the best compromised set of conditions. The adequacy of the optimized process conditions in meeting the combined goals for all responses was indicated by the composite desirability value. By using response surface methodology and optimization, coating conditions which produced coated tablets of high drug-loading efficiency, low incidences of tablet damage and low coat thickness variation were defined. Optimal conditions were found to vary over a large spectrum when different responses were considered. Changes in processing parameters across the design space did not result in drastic changes to coat quality, thereby demonstrating robustness in the Supercell coating process. © 2010 American Association of Pharmaceutical Scientists.
Source Title: AAPS PharmSciTech
ISSN: 15309932
DOI: 10.1208/s12249-010-9567-9
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