Please use this identifier to cite or link to this item:
https://doi.org/10.1007/s10895-012-1146-x
DC Field | Value | |
---|---|---|
dc.title | Optimization in solvent selection for chlorin e6 in photodynamic therapy | |
dc.contributor.author | Paul, S. | |
dc.contributor.author | Heng, P.W.S. | |
dc.contributor.author | Chan, L.W. | |
dc.date.accessioned | 2014-10-29T01:56:16Z | |
dc.date.available | 2014-10-29T01:56:16Z | |
dc.date.issued | 2013-03 | |
dc.identifier.citation | Paul, S., Heng, P.W.S., Chan, L.W. (2013-03). Optimization in solvent selection for chlorin e6 in photodynamic therapy. Journal of Fluorescence 23 (2) : 283-291. ScholarBank@NUS Repository. https://doi.org/10.1007/s10895-012-1146-x | |
dc.identifier.issn | 10530509 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/106184 | |
dc.description.abstract | The photophysical properties of chlorin e6 (Ce6) in twelve different protic, aprotic and non-polar solvents were investigated using ultraviolet-visible and fluorescence spectroscopic methods. Solvatochromic effects were determined by the changes in quantum yield, Stokes shift, fluorescence half-life and excited state dipole moments of Ce6 in the different solvents. The absorption shifts observed in different solvents were further analyzed using the Kamlet-Abboud-Taft model and the nature of solute-solvent interactions between Ce6 and different protic and aprotic solvents was elucidated. The quantum yields were found highest in protic solvents (except water), followed by aprotic and non-polar solvents. Solvent polarity parameters showed a linear increasing trend with Stokes shift and fluorescence half-life, which indicated the presence of Ce6-solvent interaction. Using the Kamlet-Abboud-Taft model, a direct correlation between the solvent polarity parameters and absorption shift was observed, which substantiated the existence of Ce6-solvent interaction by hydrogen bond formation. The excited state dipole moments in specific protic and aprotic solvents were found to be higher than the ground state dipole moments, implying a more polar nature of Ce6 during excited state transition. © 2012 Springer Science+Business Media New York. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s10895-012-1146-x | |
dc.source | Scopus | |
dc.subject | Chlorin e6 | |
dc.subject | Kamlet-Abboud-Taft model | |
dc.subject | Quantum yield | |
dc.subject | Stokes shift | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.1007/s10895-012-1146-x | |
dc.description.sourcetitle | Journal of Fluorescence | |
dc.description.volume | 23 | |
dc.description.issue | 2 | |
dc.description.page | 283-291 | |
dc.description.coden | JOFLE | |
dc.identifier.isiut | 000316018200008 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.