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Title: Optimization in solvent selection for chlorin e6 in photodynamic therapy
Authors: Paul, S.
Heng, P.W.S. 
Chan, L.W. 
Keywords: Chlorin e6
Kamlet-Abboud-Taft model
Quantum yield
Stokes shift
Issue Date: Mar-2013
Citation: Paul, S., Heng, P.W.S., Chan, L.W. (2013-03). Optimization in solvent selection for chlorin e6 in photodynamic therapy. Journal of Fluorescence 23 (2) : 283-291. ScholarBank@NUS Repository.
Abstract: The photophysical properties of chlorin e6 (Ce6) in twelve different protic, aprotic and non-polar solvents were investigated using ultraviolet-visible and fluorescence spectroscopic methods. Solvatochromic effects were determined by the changes in quantum yield, Stokes shift, fluorescence half-life and excited state dipole moments of Ce6 in the different solvents. The absorption shifts observed in different solvents were further analyzed using the Kamlet-Abboud-Taft model and the nature of solute-solvent interactions between Ce6 and different protic and aprotic solvents was elucidated. The quantum yields were found highest in protic solvents (except water), followed by aprotic and non-polar solvents. Solvent polarity parameters showed a linear increasing trend with Stokes shift and fluorescence half-life, which indicated the presence of Ce6-solvent interaction. Using the Kamlet-Abboud-Taft model, a direct correlation between the solvent polarity parameters and absorption shift was observed, which substantiated the existence of Ce6-solvent interaction by hydrogen bond formation. The excited state dipole moments in specific protic and aprotic solvents were found to be higher than the ground state dipole moments, implying a more polar nature of Ce6 during excited state transition. © 2012 Springer Science+Business Media New York.
Source Title: Journal of Fluorescence
ISSN: 10530509
DOI: 10.1007/s10895-012-1146-x
Appears in Collections:Staff Publications

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